Measles Maternal Antibodies With Low Avidity Do Not Interfere With the Establishment of Robust Quantity and Quality Antibody Responses After the Primary Dose of Measles, Mumps, and Rubella Vaccine Administered at 12-Months of Age

Overview

Journal J Pediatric Infect Dis Soc

Publisher Oxford University Press

Specialties Infectious Diseases
Pediatrics

Date 2019 Oct 24

PMID 31644795

Citations 1

Authors

Cathleen A Collins

Laura Gelinas

Linda L Yasukawa

Susette Audet

Bahaa Abu-Raya

Stuart E Turvey

Judy A Beeler

Tobias R Kollmann

Hayley A Gans

Affiliations

Soon will be listed here.

Abstract

In this study, we illustrate, for the first time, that preexisting low-avidity neutralizing measles maternal antibodies do not interfere with the development of high concentrations of high-avidity measles antibodies in children immunized at age 12 months. This suggests that the quality of measles maternal antibodies, rather than the quantity, impacts immunogenicity of primary measles immunization.

Citing Articles

Measurement of the IgG Avidity Index in the Diagnosis of Clinical Toxocariasis Patients.

Menu E, Kopec L, Luciani L, Legrand S, LOllivier C Pathogens. 2021; 10(9).

PMID: 34578119 PMC: 8468318. DOI: 10.3390/pathogens10091086.

References

Caceres V, Strebel P, Sutter R . Factors determining prevalence of maternal antibody to measles virus throughout infancy: a review. Clin Infect Dis. 2000; 31(1):110-9. DOI: 10.1086/313926. View

Albrecht P, Ennis F, Saltzman E, Krugman S . Persistence of maternal antibody in infants beyond 12 months: mechanism of measles vaccine failure. J Pediatr. 1977; 91(5):715-8. DOI: 10.1016/s0022-3476(77)81021-4. View

Nair N, Gans H, Lew-Yasukawa L, Long-Wagar A, Arvin A, Griffin D . Age-dependent differences in IgG isotype and avidity induced by measles vaccine received during the first year of life. J Infect Dis. 2007; 196(9):1339-45. DOI: 10.1086/522519. View

Niewiesk S . Maternal antibodies: clinical significance, mechanism of interference with immune responses, and possible vaccination strategies. Front Immunol. 2014; 5:446. PMC: 4165321. DOI: 10.3389/fimmu.2014.00446. View

Gans H, Arvin A, Galinus J, Logan L, DeHovitz R, Maldonado Y . Deficiency of the humoral immune response to measles vaccine in infants immunized at age 6 months. JAMA. 1998; 280(6):527-32. DOI: 10.1001/jama.280.6.527. View

Lennon J, Black F . Maternally derived measles immunity in era of vaccine-protected mothers. J Pediatr. 1986; 108(5 Pt 1):671-6. DOI: 10.1016/s0022-3476(86)81039-3. View

Gans H, Yasukawa L, Sung P, Sullivan B, DeHovitz R, Audet S . Measles humoral and cell-mediated immunity in children aged 5-10 years after primary measles immunization administered at 6 or 9 months of age. J Infect Dis. 2013; 207(4):574-82. PMC: 3549597. DOI: 10.1093/infdis/jis719. View

Corbett N, Blimkie D, Ho K, Cai B, Sutherland D, Kallos A . Ontogeny of Toll-like receptor mediated cytokine responses of human blood mononuclear cells. PLoS One. 2010; 5(11):e15041. PMC: 2994830. DOI: 10.1371/journal.pone.0015041. View

Odegard V, Schatz D . Targeting of somatic hypermutation. Nat Rev Immunol. 2006; 6(8):573-83. DOI: 10.1038/nri1896. View

10.

Chen R, Markowitz L, Albrecht P, Stewart J, Mofenson L, Preblud S . Measles antibody: reevaluation of protective titers. J Infect Dis. 1990; 162(5):1036-42. DOI: 10.1093/infdis/162.5.1036. View

11.

Leuridan E, Hens N, Hutse V, Ieven M, Aerts M, Van Damme P . Early waning of maternal measles antibodies in era of measles elimination: longitudinal study. BMJ. 2010; 340:c1626. DOI: 10.1136/bmj.c1626. View

12.

Dorner T, Radbruch A . Antibodies and B cell memory in viral immunity. Immunity. 2007; 27(3):384-92. DOI: 10.1016/j.immuni.2007.09.002. View