[Radiomics for Prediction of Central Lymph Node Metastasis in the Neck in Patients with Thyroid Papillary Carcinoma]

Overview

Journal Nan Fang Yi Ke Da Xue Xue Bao

Specialty General Medicine

Date 2019 Oct 24

PMID 31640963

Citations 3

Authors

Weizhen Wang

Yingjia Li

Affiliations

Soon will be listed here.

Abstract

Objective: To explore the feasibility of radiomics for predicting lymph node metastasis in the central region of the neck in patients with thyroid papillary carcinoma (PTC).

Methods: A total of 189 patients with PTC confirmed by thyroid fine needle aspiration biopsy were prospectively enrolled in this study. The cross-sectional and longitudinal ultrasound images and the images of both sections were analyzed for predicting central lymph node metastasis using a radiomics approach with pathological results as the gold standard.

Results: In the 189 patients, the accuracy, sensitivity and specificity of preoperative thyroid ultrasonography for diagnosis of central lymph node metastasis was 69.39%, 64% and 73%, respectively. Based on the ultrasound images of the cross-sections, longitudinal sections and both sections, the accuracy, sensitivity and specificity of radiomics for predicting central lymph node metastasis was 66.06%/68.12%/77.69%, 53%/46%/40%, and 52%/53%/51%, respectively.

Conclusions: Radiomics with combined analysis of the ultrasound images on the cross-section and longitudinal section images achieves a higher accuracy for predicting central lymph node metastasis than analysis a single section, and its diagnostic accuracy is much higher than that of conventional ultrasound examination.

Citing Articles

An integrated model incorporating deep learning, hand-crafted radiomics and clinical and US features to diagnose central lymph node metastasis in patients with papillary thyroid cancer.

Gao Y, Wang W, Yang Y, Xu Z, Lin Y, Lang T BMC Cancer. 2024; 24(1):69.

PMID: 38216936 PMC: 10787418. DOI: 10.1186/s12885-024-11838-1.

The progress of radiomics in thyroid nodules.

Gao X, Ran X, Ding W Front Oncol. 2023; 13:1109319.

PMID: 36959790 PMC: 10029726. DOI: 10.3389/fonc.2023.1109319.

Machine Learning: Applications and Advanced Progresses of Radiomics in Endocrine Neoplasms.

Wang Y, Zhang L, Qi L, Yi X, Li M, Zhou M J Oncol. 2021; 2021:8615450.

PMID: 34671399 PMC: 8523238. DOI: 10.1155/2021/8615450.

References

Wu S, Zheng J, Li Y, Yu H, Shi S, Xie W . A Radiomics Nomogram for the Preoperative Prediction of Lymph Node Metastasis in Bladder Cancer. Clin Cancer Res. 2017; 23(22):6904-6911. DOI: 10.1158/1078-0432.CCR-17-1510. View

Gillies R, Kinahan P, Hricak H . Radiomics: Images Are More than Pictures, They Are Data. Radiology. 2015; 278(2):563-77. PMC: 4734157. DOI: 10.1148/radiol.2015151169. View

Hartl D, Mamelle E, Borget I, Leboulleux S, Mirghani H, Schlumberger M . Influence of prophylactic neck dissection on rate of retreatment for papillary thyroid carcinoma. World J Surg. 2013; 37(8):1951-8. DOI: 10.1007/s00268-013-2089-3. View

Leenhardt L, Bernier M, Boin-Pineau M, Conte Devolx B, Marechaud R, Niccoli-Sire P . Advances in diagnostic practices affect thyroid cancer incidence in France. Eur J Endocrinol. 2004; 150(2):133-9. DOI: 10.1530/eje.0.1500133. View

Mazzaferri E, Kloos R . Clinical review 128: Current approaches to primary therapy for papillary and follicular thyroid cancer. J Clin Endocrinol Metab. 2001; 86(4):1447-63. DOI: 10.1210/jcem.86.4.7407. View

Popadich A, Levin O, Lee J, Smooke-Praw S, Ro K, Fazel M . A multicenter cohort study of total thyroidectomy and routine central lymph node dissection for cN0 papillary thyroid cancer. Surgery. 2011; 150(6):1048-57. DOI: 10.1016/j.surg.2011.09.003. View

Ahn B, Kim J, Jeong H, Lee J, Chang E, Kim Y . Predictive factors of central lymph node metastasis in papillary thyroid carcinoma. Ann Surg Treat Res. 2015; 88(2):63-8. PMC: 4325652. DOI: 10.4174/astr.2015.88.2.63. View

Nam S, Shin J, Han B, Ko E, Ko E, Hahn S . Preoperative ultrasonographic features of papillary thyroid carcinoma predict biological behavior. J Clin Endocrinol Metab. 2013; 98(4):1476-82. DOI: 10.1210/jc.2012-4072. View

Chen Q, Wei T, Wang X, Li Z, Du Z, Zhu J . The total number of prelaryngeal and pretracheal lymph node metastases: is it a reliable predictor of contralateral central lymph node metastasis in papillary thyroid carcinoma?. J Surg Res. 2017; 214:162-167. DOI: 10.1016/j.jss.2015.02.056. View

10.

Lim H, Devesa S, Sosa J, Check D, Kitahara C . Trends in Thyroid Cancer Incidence and Mortality in the United States, 1974-2013. JAMA. 2017; 317(13):1338-1348. PMC: 8216772. DOI: 10.1001/jama.2017.2719. View

11.

Zhang Y, Luo Y, Zhang M, Yang M, Zhang Y, Li J . Value of Contrast-enhanced Ultrasound and Conventional Ultrasound in the Diagnosis of Papillary Thyroid Carcinoma with Cervical Lymph Node Metastases. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 2017; 39(2):177-182. DOI: 10.3881/j.issn.1000-503X.2017.02.003. View

12.

Lee H, Park H, Kim S, Choi G, Park H, Hong J . Clinical characteristics of papillary thyroid microcarcinoma less than or equal to 5 mm on ultrasonography. Eur Arch Otorhinolaryngol. 2013; 270(11):2969-74. DOI: 10.1007/s00405-013-2634-6. View

13.

Du L, Wang Y, Sun X, Li H, Geng X, Ge M . Thyroid cancer: trends in incidence, mortality and clinical-pathological patterns in Zhejiang Province, Southeast China. BMC Cancer. 2018; 18(1):291. PMC: 5856225. DOI: 10.1186/s12885-018-4081-7. View

14.

Patel N, McKinney K, Kreidler S, Bieker T, Russ P, Roberts K . Ultrasound-based clinical prediction rule model for detecting papillary thyroid cancer in cervical lymph nodes: A pilot study. J Clin Ultrasound. 2015; 44(3):143-51. DOI: 10.1002/jcu.22309. View

15.

Ji Y, Yoo H, Song C, Park C, Lee C, Tae K . Predictive factors and pattern of central lymph node metastasis in unilateral papillary thyroid carcinoma. Auris Nasus Larynx. 2015; 43(1):79-83. DOI: 10.1016/j.anl.2015.09.005. View

16.

Huang Y, Liang C, He L, Tian J, Liang C, Chen X . Development and Validation of a Radiomics Nomogram for Preoperative Prediction of Lymph Node Metastasis in Colorectal Cancer. J Clin Oncol. 2016; 34(18):2157-64. DOI: 10.1200/JCO.2015.65.9128. View

17.

Yoo H, Shin M, Ji Y, Song C, Lee S, Tae K . Optimal extent of prophylactic central neck dissection for papillary thyroid carcinoma: Comparison of unilateral versus bilateral central neck dissection. Asian J Surg. 2017; 41(4):363-369. DOI: 10.1016/j.asjsur.2017.03.002. View

18.

Lambin P, Rios-Velazquez E, Leijenaar R, Carvalho S, van Stiphout R, Granton P . Radiomics: extracting more information from medical images using advanced feature analysis. Eur J Cancer. 2012; 48(4):441-6. PMC: 4533986. DOI: 10.1016/j.ejca.2011.11.036. View

19.

Vallieres M, Freeman C, Skamene S, El Naqa I . A radiomics model from joint FDG-PET and MRI texture features for the prediction of lung metastases in soft-tissue sarcomas of the extremities. Phys Med Biol. 2015; 60(14):5471-96. DOI: 10.1088/0031-9155/60/14/5471. View

20.

Liu T, Zhou S, Yu J, Guo Y, Wang Y, Zhou J . Prediction of Lymph Node Metastasis in Patients With Papillary Thyroid Carcinoma: A Radiomics Method Based on Preoperative Ultrasound Images. Technol Cancer Res Treat. 2019; 18:1533033819831713. PMC: 6429647. DOI: 10.1177/1533033819831713. View