A First Case Report of Subependymoma in Mutation-Associated Noonan Syndrome

Overview

Journal Case Rep Neurol Med

Publisher Wiley

Specialty Neurology

Date 2019 Oct 23

PMID 31637070

Citations 5

Authors

Boonchai Boonyawat

Mongkon Charoenpitakchai

Piradee Suwanpakdee

Affiliations

Soon will be listed here.

Abstract

Noonan syndrome (NS) is an autosomal dominant disorder in some cases caused by mutations. Since somatic mutations in are seen in several tumor types, NS which causes germline mutations are also increase the risk of hematologic malignancies and brain solid tumors. However, the report of brain tumors in Noonan syndrome remains rather rare. Here, we report the first case of an 11-year-old Thai boy with Noonan syndrome who presented with symptoms related to hydrocephalus secondary to subependymoma in the fourth ventricle, and mutation was identified in this patient.

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