Aβ Seeding As a Tool to Study Cerebral Amyloidosis and Associated Pathology

Overview

Journal Front Mol Neurosci

Specialty Molecular Biology

Date 2019 Oct 22

PMID 31632238

Citations 19

Authors

Marina Friesen

Melanie Meyer-Luehmann

Affiliations

Soon will be listed here.

Abstract

Misfolded proteins can form aggregates and induce a self-perpetuating process leading to the amplification and spreading of pathological protein assemblies. These misfolded protein assemblies act as seeds of aggregation. In an exogenous seeding model, both the features of seeds and the position at which seeding originates are precisely defined. Ample evidence from studies on intracerebal injection of amyloid-beta (Aβ)-rich brain extracts suggests that Aβ aggregation can be initiated by prion-like seeding. In this mini-review article, we will summarize the past and current literature on Aβ seeding in mouse models of AD and discuss its implementation as a tool to study cerebral amyloidosis and associated pathology.

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