Effect on Platelet Function of Metal-Based Nanoparticles Developed for Medical Applications

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2019 Oct 18

PMID 31620449

Citations 9

Authors

Nadhim Kamil Hante

Carlos Medina

Maria Jose Santos-Martinez

Affiliations

Soon will be listed here.

Abstract

Nanomaterials have been recently introduced as potential diagnostic and therapeutic tools in the medical field. One of the main concerns in relation to the use of nanomaterials in humans is their potential toxicity profile and blood compatibility. In fact, and due to their small size, NPs can translocate into the systemic circulation even after dermal contact, inhalation, or oral ingestion. Once in the blood stream, nanoparticles become in contact with the different components of the blood and can potentially interfere with normal platelet function leading to bleeding or thrombosis. Metallic NPs have been already used for diagnosis and treatment purposes due to their unique characteristics. However, the potential interactions between metallic NPs and platelets has not been widely studied and reported. This review focuses on the factors that can affect platelet activation and aggregation by metal NPs and the nature of such interactions, providing a summary of the effect of various metal NPs on platelet function available in the literature.

Citing Articles

PAMAM-Calix-Dendrimers: Third Generation Synthesis and Impact of Generation and Macrocyclic Core Conformation on Hemotoxicity and Calf Thymus DNA Binding.

Mostovaya O, Shiabiev I, Ovchinnikov D, Pysin D, Mukhametzyanov T, Stanavaya A Pharmaceutics. 2024; 16(11).

PMID: 39598503 PMC: 11597237. DOI: 10.3390/pharmaceutics16111379.

A double-edged sword: The complex interplay between engineered nanoparticles and platelets.

Asaad Y, Nemcovsky-Amar D, Sznitman J, Mangin P, Korin N Bioeng Transl Med. 2024; 9(4):e10669.

PMID: 39036095 PMC: 11256164. DOI: 10.1002/btm2.10669.

Antifungal and Coagulation Properties of a Copper (I) Oxide Nanopowder Produced by Out-of-Phase Pulsed Sonoelectrochemistry.

Mancier V, Fattoum S, Haguet H, Laloy J, Maillet C, Gangloff S Antibiotics (Basel). 2024; 13(3).

PMID: 38534722 PMC: 10967388. DOI: 10.3390/antibiotics13030286.

evaluation of iron oxide nanoparticle-induced thromboinflammatory response using a combined human whole blood and endothelial cell model.

Gerogianni A, Bal M, Mohlin C, Woodruff T, Lambris J, Mollnes T Front Immunol. 2023; 14:1101387.

PMID: 37081885 PMC: 10111002. DOI: 10.3389/fimmu.2023.1101387.

Gold-Nanoparticle Hybrid Nanostructures for Multimodal Cancer Therapy.

Ali A, Abuwatfa W, Al-Sayah M, Husseini G Nanomaterials (Basel). 2022; 12(20).

PMID: 36296896 PMC: 9608376. DOI: 10.3390/nano12203706.

References

Huff T, Tong L, Zhao Y, Hansen M, Cheng J, Wei A . Hyperthermic effects of gold nanorods on tumor cells. Nanomedicine (Lond). 2007; 2(1):125-32. PMC: 2597406. DOI: 10.2217/17435889.2.1.125. View

Bouwmeester H, Lynch I, Marvin H, Dawson K, Berges M, Braguer D . Minimal analytical characterization of engineered nanomaterials needed for hazard assessment in biological matrices. Nanotoxicology. 2011; 5(1):1-11. DOI: 10.3109/17435391003775266. View

Sayes C, Wahi R, Kurian P, Liu Y, West J, Ausman K . Correlating nanoscale titania structure with toxicity: a cytotoxicity and inflammatory response study with human dermal fibroblasts and human lung epithelial cells. Toxicol Sci. 2006; 92(1):174-85. DOI: 10.1093/toxsci/kfj197. View

Mallipeddi R, Rohan L . Nanoparticle-based vaginal drug delivery systems for HIV prevention. Expert Opin Drug Deliv. 2009; 7(1):37-48. DOI: 10.1517/17425240903338055. View

Tsai C, Shiau A, Chen S, Chen Y, Cheng P, Chang M . Amelioration of collagen-induced arthritis in rats by nanogold. Arthritis Rheum. 2007; 56(2):544-54. DOI: 10.1002/art.22401. View

Mishra Y, Adelung R, Rohl C, Shukla D, Spors F, Tiwari V . Virostatic potential of micro-nano filopodia-like ZnO structures against herpes simplex virus-1. Antiviral Res. 2011; 92(2):305-12. PMC: 4148000. DOI: 10.1016/j.antiviral.2011.08.017. View

Bobo D, Robinson K, Islam J, Thurecht K, Corrie S . Nanoparticle-Based Medicines: A Review of FDA-Approved Materials and Clinical Trials to Date. Pharm Res. 2016; 33(10):2373-87. DOI: 10.1007/s11095-016-1958-5. View

Sun C, Ma M, Yang J, Zhang Y, Chen P, Huang W . Phase-controlled synthesis of α-NiS nanoparticles confined in carbon nanorods for high performance supercapacitors. Sci Rep. 2014; 4:7054. PMC: 4231331. DOI: 10.1038/srep07054. View

Khalili Fard J, Jafari S, Eghbal M . A Review of Molecular Mechanisms Involved in Toxicity of Nanoparticles. Adv Pharm Bull. 2016; 5(4):447-54. PMC: 4729339. DOI: 10.15171/apb.2015.061. View

10.

Huang H, Lai W, Cui M, Liang L, Lin Y, Fang Q . An Evaluation of Blood Compatibility of Silver Nanoparticles. Sci Rep. 2016; 6:25518. PMC: 4857076. DOI: 10.1038/srep25518. View

11.

Strojan K, Leonardi A, Bregar V, Krizaj I, Svete J, Pavlin M . Dispersion of Nanoparticles in Different Media Importantly Determines the Composition of Their Protein Corona. PLoS One. 2017; 12(1):e0169552. PMC: 5215476. DOI: 10.1371/journal.pone.0169552. View

12.

Gratton S, Ropp P, Pohlhaus P, Luft J, Madden V, Napier M . The effect of particle design on cellular internalization pathways. Proc Natl Acad Sci U S A. 2008; 105(33):11613-8. PMC: 2575324. DOI: 10.1073/pnas.0801763105. View

13.

Lundqvist M, Stigler J, Elia G, Lynch I, Cedervall T, Dawson K . Nanoparticle size and surface properties determine the protein corona with possible implications for biological impacts. Proc Natl Acad Sci U S A. 2008; 105(38):14265-70. PMC: 2567179. DOI: 10.1073/pnas.0805135105. View

14.

Ilinskaya A, Shah A, Enciso A, Chan K, Kaczmarczyk J, Blonder J . Nanoparticle physicochemical properties determine the activation of intracellular complement. Nanomedicine. 2019; 17:266-275. PMC: 6520145. DOI: 10.1016/j.nano.2019.02.002. View

15.

Shrivastava S, Bera T, Singh S, Singh G, Ramachandrarao P, Dash D . Characterization of antiplatelet properties of silver nanoparticles. ACS Nano. 2009; 3(6):1357-64. DOI: 10.1021/nn900277t. View

16.

Santos-Martinez M, Tomaszewski K, Medina C, Bazou D, Gilmer J, Radomski M . Pharmacological characterization of nanoparticle-induced platelet microaggregation using quartz crystal microbalance with dissipation: comparison with light aggregometry. Int J Nanomedicine. 2015; 10:5107-19. PMC: 4540170. DOI: 10.2147/IJN.S84305. View

17.

Lesniak A, Salvati A, Santos-Martinez M, Radomski M, Dawson K, Aberg C . Nanoparticle adhesion to the cell membrane and its effect on nanoparticle uptake efficiency. J Am Chem Soc. 2013; 135(4):1438-44. DOI: 10.1021/ja309812z. View

18.

He Y, Xu J, Sun X, Ren X, Maharjan A, York P . Cuboidal tethered cyclodextrin frameworks tailored for hemostasis and injured vessel targeting. Theranostics. 2019; 9(9):2489-2504. PMC: 6525997. DOI: 10.7150/thno.31159. View

19.

Holzer M, Bihari P, Praetner M, Uhl B, Reichel C, Fent J . Carbon-based nanomaterials accelerate arteriolar thrombus formation in the murine microcirculation independently of their shape. J Appl Toxicol. 2014; 34(11):1167-76. DOI: 10.1002/jat.2996. View

20.

Jin H, Heller D, Sharma R, Strano M . Size-dependent cellular uptake and expulsion of single-walled carbon nanotubes: single particle tracking and a generic uptake model for nanoparticles. ACS Nano. 2009; 3(1):149-58. DOI: 10.1021/nn800532m. View