Candidate Single Nucleotide Polymorphisms of Irritable Bowel Syndrome: a Systemic Review and Meta-analysis

Overview

Journal BMC Gastroenterol

Publisher Biomed Central

Specialty Gastroenterology

Date 2019 Oct 17

PMID 31615448

Citations 7

Authors

Shiwei Zhu

Ben Wang

Qiong Jia

Liping Duan

Affiliations

Soon will be listed here.

Abstract

Background: Genetic factors increase the risk of irritable bowel syndrome (IBS). Analysis of single nucleotide polymorphisms (SNPs) has been used in IBS patients, but the findings are inconsistent. The goal of this review was to synthesize all the published SNPs studies of IBS through meta-analysis to objectively evaluate the relevance of SNPs to IBS risks.

Methods: IBS - related polymorphisms studies from 2000 to 2018 were searched. Pooled odds ratios with a 95% confidence interval for each SNP were evaluated through five genetic models. Ethnicity, ROME criteria and IBS subtypes were defined for subgroup analyze.

Results: Ten relevant genes were evaluated. SNPs rs4263839 and rs6478108 of TNFSF15 associated with an increased risk of IBS; IL6 rs1800795 increased the risk for Caucasian IBS patients which diagnosed by Rome III criteria; and IL23R rs11465804 increased the risk for IBS-C patients. IL10 rs1800896 GG genotype associated with a decreased risk of IBS. No evidence supported the association of GNβ3 rs5443, TNFα rs1800629, and IL10 rs1800871 to IBS in this study.

Conclusions: This meta-analysis presents an in-depth overview for IBS SNPs analysis. It was confirmed that polymorphisms of TNFSF15 associated with increased IBS risk, while IL10 rs1800896 associated with decreased IBS risk. It might offer some insights into polymorphisms of inflammation factors which might affect IBS susceptibility. Moreover, the analysis also emphasizes the importance of diagnostic criteria and phenotype homogeneity in IBS genetic studies.

Citing Articles

Risk factors for developing irritable bowel syndrome: systematic umbrella review of reviews.

Sulaimi F, Ong T, Tang A, Quek J, Pillay R, Low D BMC Med. 2025; 23(1):103.

PMID: 39985070 PMC: 11846330. DOI: 10.1186/s12916-025-03930-5.

Genetic associations and potential mediators between psychiatric disorders and irritable bowel syndrome: a Mendelian randomization study with mediation analysis.

Zhang T, Chen Y, Li X, Zhang J, Duan L Front Psychiatry. 2024; 15:1279266.

PMID: 38352653 PMC: 10861787. DOI: 10.3389/fpsyt.2024.1279266.

Evaluation of the Impact of Some Single-Nucleotide Gene Polymorphisms on the Development of Adenomatous Polyps of the Colon in Patients with Irritable Bowel Syndrome.

Kyrian O, Dorofeyev A, Derkach I, Zhigal Y Turk J Gastroenterol. 2023; 34(8):822-830.

PMID: 37404119 PMC: 10544543. DOI: 10.5152/tjg.2023.21985.

The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome.

Zhao T, Zhang Y, Lee J, Starkweather A, Young E, Cong X J Pers Med. 2022; 12(2).

PMID: 35207633 PMC: 8878682. DOI: 10.3390/jpm12020142.

Milestones of Precision Medicine: An Innovative, Multidisciplinary Overview.

Garcia-Foncillas J, Argente J, Bujanda L, Cardona V, Casanova B, Fernandez-Montes A Mol Diagn Ther. 2021; 25(5):563-576.

PMID: 34331269 DOI: 10.1007/s40291-021-00544-4.

References

Compare D, Rocco A, Coccoli P, Angrisani D, Sgamato C, Iovine B . Lactobacillus casei DG and its postbiotic reduce the inflammatory mucosal response: an ex-vivo organ culture model of post-infectious irritable bowel syndrome. BMC Gastroenterol. 2017; 17(1):53. PMC: 5391611. DOI: 10.1186/s12876-017-0605-x. View

Holtmann G, Ford A, Talley N . Pathophysiology of irritable bowel syndrome. Lancet Gastroenterol Hepatol. 2017; 1(2):133-146. DOI: 10.1016/S2468-1253(16)30023-1. View

Czogalla B, Schmitteckert S, Houghton L, Sayuk G, Camilleri M, Olivo-Diaz A . A meta-analysis of immunogenetic Case-Control Association Studies in irritable bowel syndrome. Neurogastroenterol Motil. 2015; 27(5):717-27. DOI: 10.1111/nmo.12548. View

Wang Y, Wu Z, Qiao H, Zhang Y . A genetic association study of single nucleotide polymorphisms in GNβ3 and COMT in elderly patients with irritable bowel syndrome. Med Sci Monit. 2014; 20:1246-54. PMC: 4113520. DOI: 10.12659/MSM.890315. View

Zhang Z, Duan Z, Wang L, Yang D, Zhao G, Zhang L . The serotonin transporter gene polymorphism (5-HTTLPR) and irritable bowel syndrome: a meta-analysis of 25 studies. BMC Gastroenterol. 2014; 14:23. PMC: 3926682. DOI: 10.1186/1471-230X-14-23. View

Liu J, van Sommeren S, Huang H, Ng S, Alberts R, Takahashi A . Association analyses identify 38 susceptibility loci for inflammatory bowel disease and highlight shared genetic risk across populations. Nat Genet. 2015; 47(9):979-986. PMC: 4881818. DOI: 10.1038/ng.3359. View

Waehrens R, Li X, Sundquist J, Sundquist K, Zoller B . Perinatal and familial risk factors for irritable bowel syndrome in a Swedish national cohort. Scand J Gastroenterol. 2017; 53(5):559-566. DOI: 10.1080/00365521.2017.1398345. View

Beyder A, Mazzone A, Strege P, Tester D, Saito Y, Bernard C . Loss-of-function of the voltage-gated sodium channel NaV1.5 (channelopathies) in patients with irritable bowel syndrome. Gastroenterology. 2014; 146(7):1659-1668. PMC: 4096335. DOI: 10.1053/j.gastro.2014.02.054. View

Brant S, Okou D, Simpson C, Cutler D, Haritunians T, Bradfield J . Genome-Wide Association Study Identifies African-Specific Susceptibility Loci in African Americans With Inflammatory Bowel Disease. Gastroenterology. 2016; 152(1):206-217.e2. PMC: 5164948. DOI: 10.1053/j.gastro.2016.09.032. View

10.

Slebioda T, Bojarska-Junak A, Cyman M, Landowski P, Kaminska B, Celinski K . Expression of death receptor 3 on peripheral blood mononuclear cells differes in adult IBD patients and children with newly diagnosed IBD. Cytometry B Clin Cytom. 2016; 92(2):165-169. DOI: 10.1002/cyto.b.21372. View

11.

Kim H, Camilleri M, Carlson P, Cremonini F, Ferber I, Stephens D . Association of distinct alpha(2) adrenoceptor and serotonin transporter polymorphisms with constipation and somatic symptoms in functional gastrointestinal disorders. Gut. 2004; 53(6):829-37. PMC: 1774073. DOI: 10.1136/gut.2003.030882. View

12.

Ek W, Reznichenko A, Ripke S, Niesler B, Zucchelli M, Rivera N . Exploring the genetics of irritable bowel syndrome: a GWA study in the general population and replication in multinational case-control cohorts. Gut. 2014; 64(11):1774-82. DOI: 10.1136/gutjnl-2014-307997. View

13.

Bashashati M, Rezaei N, Bashashati H, Shafieyoun A, Daryani N, Sharkey K . Cytokine gene polymorphisms are associated with irritable bowel syndrome: a systematic review and meta-analysis. Neurogastroenterol Motil. 2012; 24(12):1102-e566. DOI: 10.1111/j.1365-2982.2012.01990.x. View

14.

Orand A, Gupta A, Shih W, Presson A, Hammer C, Niesler B . Catecholaminergic Gene Polymorphisms Are Associated with GI Symptoms and Morphological Brain Changes in Irritable Bowel Syndrome. PLoS One. 2015; 10(8):e0135910. PMC: 4546052. DOI: 10.1371/journal.pone.0135910. View

15.

Kalantar J, Locke 3rd G, Zinsmeister A, Beighley C, Talley N . Familial aggregation of irritable bowel syndrome: a prospective study. Gut. 2003; 52(12):1703-7. PMC: 1773907. DOI: 10.1136/gut.52.12.1703. View

16.

Ahn K, Haynes C, Kim W, St Fleur R, Gordon D, Finch S . The effects of SNP genotyping errors on the power of the Cochran-Armitage linear trend test for case/control association studies. Ann Hum Genet. 2006; 71(Pt 2):249-61. DOI: 10.1111/j.1469-1809.2006.00318.x. View

17.

Henstrom M, DAmato M . Genetics of irritable bowel syndrome. Mol Cell Pediatr. 2016; 3(1):7. PMC: 4752571. DOI: 10.1186/s40348-016-0038-6. View

18.

Romero P, Schmitteckert S, Wouters M, Houghton L, Czogalla B, Sayuk G . No association between the common calcium-sensing receptor polymorphism rs1801725 and irritable bowel syndrome. BMC Med Genet. 2015; 16:110. PMC: 4676826. DOI: 10.1186/s12881-015-0256-0. View

19.

Li H, Song J, Niu G, Zhang H, Guo J, Shih D . TL1A blocking ameliorates intestinal fibrosis in the T cell transfer model of chronic colitis in mice. Pathol Res Pract. 2017; 214(2):217-227. DOI: 10.1016/j.prp.2017.11.017. View

20.

Qin S, Jiang H, Lu D, Zhou Y . Association of interleukin-10 polymorphisms with risk of irritable bowel syndrome: a meta-analysis. World J Gastroenterol. 2014; 19(48):9472-80. PMC: 3882424. DOI: 10.3748/wjg.v19.i48.9472. View