Korean Traditional Medicine () Ameliorates Colitis by Regulating Gut Microbiota

Overview

Journal Metabolites

Publisher MDPI

Date 2019 Oct 17

PMID 31615012

Citations 6

Authors

Seung-Ho Seo

Tatsuya Unno

Seong-Eun Park

Eun-Ju Kim

Yu-Mi Lee

Chang-Su Na

Hong-Seok Son

Affiliations

Soon will be listed here.

Abstract

The objective of this study was to examine the anti-colitis activity of (JGT) in dextran sulfate sodium (DSS)-induced colitis and explore changes of the gut microbial community using 16S rRNA amplicon sequencing and metabolomics approaches. It was found that treatment with JGT or 5-aminosalicylic acid (5-ASA) alleviated the severity of colitis symptoms by suppressing inflammatory cytokine levels of IL-6, IL-12, and IFN-γ. The non-metric multidimensional scaling analysis of gut microbiome revealed that JGT groups were clearly separated from the DSS group, suggesting that JGT administration altered gut microbiota. The operational taxonomic units (OTUs) that were decreased by DSS but increased by JGT include and . On the other hand, OTUs that were increased by DSS but decreased by 5-ASA or JGT treatments include Bacteroidales S24-7, Ruminococcaceae, and Rikenellaceae, and the genera , , , and . After JGT administration, the metabolites, including most amino acids and lactic acid that were altered by colitis induction, became similar to those of the control group. This study demonstrates that JGT might have potential to effectively treat colitis by restoring dysbiosis of gut microbiota and host metabolites.

Citing Articles

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