Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film

Overview

Journal Materials (Basel)

Publisher MDPI

Date 2019 Oct 17

PMID 31614998

Citations 9

Authors

Xiaoning Zhang

Zhenyu Chen

Hong Bao

Jianwei Liang

Shui Xu

Guotao Cheng

Yong Zhu

Affiliations

Soon will be listed here.

Abstract

In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it was found that the prepared SF/Gly/GA/Cur film possessed the capability to effectively inhibit the growth of bacteria and prevent bacterial penetration with a suitable water vapor transmission rate. Furthermore, the prepared composite film was non-cytotoxic, which makes it an ideal material for wound dressings.

Citing Articles

Natural Protein Films from Textile Waste for Wound Healing and Wound Dressing Applications.

Ottaviano L, Buoso S, Zamboni R, Sotgiu G, Posati T J Funct Biomater. 2025; 16(1).

PMID: 39852576 PMC: 11766051. DOI: 10.3390/jfb16010020.

Resorbable Membranes for Guided Bone Regeneration: Critical Features, Potentials, and Limitations.

Abtahi S, Chen X, Shahabi S, Nasiri N ACS Mater Au. 2023; 3(5):394-417.

PMID: 38089090 PMC: 10510521. DOI: 10.1021/acsmaterialsau.3c00013.

In Vitro and In Vivo Characterization Methods for Evaluation of Modern Wound Dressings.

Ahmad N Pharmaceutics. 2023; 15(1).

PMID: 36678671 PMC: 9864730. DOI: 10.3390/pharmaceutics15010042.

Optically Clear Silk Fibroin Films with Tunable Properties for Potential Corneal Tissue Engineering Applications: A Process-Property-Function Relationship Study.

Beena M, Ameer J, Kasoju N ACS Omega. 2022; 7(34):29634-29646.

PMID: 36061739 PMC: 9434766. DOI: 10.1021/acsomega.2c01579.

A Comprehensive Review on the Benefits and Problems of Curcumin with Respect to Human Health.

Liu S, Liu J, He L, Liu L, Cheng B, Zhou F Molecules. 2022; 27(14).

PMID: 35889273 PMC: 9319031. DOI: 10.3390/molecules27144400.

References

Vasconcelos A, Freddi G, Cavaco-Paulo A . Biodegradable materials based on silk fibroin and keratin. Biomacromolecules. 2008; 9(4):1299-305. DOI: 10.1021/bm7012789. View

Farokhi M, Mottaghitalab F, Fatahi Y, Khademhosseini A, Kaplan D . Overview of Silk Fibroin Use in Wound Dressings. Trends Biotechnol. 2018; 36(9):907-922. DOI: 10.1016/j.tibtech.2018.04.004. View

Koh L, Yeo J, Lee Y, Ong Q, Han M, Tee B . Advancing the frontiers of silk fibroin protein-based materials for futuristic electronics and clinical wound-healing (Invited review). Mater Sci Eng C Mater Biol Appl. 2018; 86:151-172. DOI: 10.1016/j.msec.2018.01.007. View

Queen D, Gaylor J, Evans J, Courtney J, Reid W . The preclinical evaluation of the water vapour transmission rate through burn wound dressings. Biomaterials. 1987; 8(5):367-71. DOI: 10.1016/0142-9612(87)90007-x. View

Gong C, Shan M, Li B, Wu G . Injectable dual redox responsive diselenide-containing poly(ethylene glycol) hydrogel. J Biomed Mater Res A. 2017; 105(9):2451-2460. DOI: 10.1002/jbm.a.36103. View

Zhang W, Chen L, Chen J, Wang L, Gui X, Ran J . Silk Fibroin Biomaterial Shows Safe and Effective Wound Healing in Animal Models and a Randomized Controlled Clinical Trial. Adv Healthc Mater. 2017; 6(10). DOI: 10.1002/adhm.201700121. View

Velnar T, Bailey T, Smrkolj V . The wound healing process: an overview of the cellular and molecular mechanisms. J Int Med Res. 2009; 37(5):1528-42. DOI: 10.1177/147323000903700531. View

Piskozub Z . The efficiency of wound dressing materials as a barrier to secondary bacterial contamination. Br J Plast Surg. 1968; 21(4):387-401. DOI: 10.1016/s0007-1226(68)80069-4. View

Zhang X, Bao H, Donley C, Liang J, Yang S, Xu S . Thiolation and characterization of regenerated silk fibroin films with reduced glutathione. BMC Chem. 2019; 13(1):62. PMC: 6661838. DOI: 10.1186/s13065-019-0583-x. View

10.

Richards F, Knowles J . Glutaraldehyde as a protein cross-linkage reagent. J Mol Biol. 1968; 37(1):231-3. DOI: 10.1016/0022-2836(68)90086-7. View

11.

Bhardwaj N, Rajkhowa R, Wang X, Devi D . Milled non-mulberry silk fibroin microparticles as biomaterial for biomedical applications. Int J Biol Macromol. 2015; 81:31-40. DOI: 10.1016/j.ijbiomac.2015.07.049. View

12.

Yu K, Lu F, Li Q, Chen H, Lu B, Liu J . In situ assembly of Ag nanoparticles (AgNPs) on porous silkworm cocoon-based wound film: enhanced antimicrobial and wound healing activity. Sci Rep. 2017; 7(1):2107. PMC: 5437089. DOI: 10.1038/s41598-017-02270-6. View

13.

Xie M, Fan D, Zhao Z, Li Z, Li G, Chen Y . Nano-curcumin prepared via supercritical: Improved anti-bacterial, anti-oxidant and anti-cancer efficacy. Int J Pharm. 2015; 496(2):732-40. DOI: 10.1016/j.ijpharm.2015.11.016. View

14.

Kasoju N, Bora U . Fabrication and characterization of curcumin-releasing silk fibroin scaffold. J Biomed Mater Res B Appl Biomater. 2012; 100(7):1854-66. DOI: 10.1002/jbm.b.32753. View

15.

Liu T, Miao J, Sheng W, Xie Y, Huang Q, Shan Y . Cytocompatibility of regenerated silk fibroin film: a medical biomaterial applicable to wound healing. J Zhejiang Univ Sci B. 2010; 11(1):10-6. PMC: 2801084. DOI: 10.1631/jzus.B0900163. View

16.

Chen X, Shao Z, Marinkovic N, Miller L, Zhou P, Chance M . Conformation transition kinetics of regenerated Bombyx mori silk fibroin membrane monitored by time-resolved FTIR spectroscopy. Biophys Chem. 2001; 89(1):25-34. DOI: 10.1016/s0301-4622(00)00213-1. View

17.

Lu Q, Hu X, Wang X, Kluge J, Lu S, Cebe P . Water-insoluble silk films with silk I structure. Acta Biomater. 2009; 6(4):1380-7. PMC: 2830340. DOI: 10.1016/j.actbio.2009.10.041. View

18.

Li L, Teller S, Clifton R, Jia X, Kiick K . Tunable mechanical stability and deformation response of a resilin-based elastomer. Biomacromolecules. 2011; 12(6):2302-10. PMC: 3139215. DOI: 10.1021/bm200373p. View

19.

Schreml S, Szeimies R, Prantl L, Landthaler M, Babilas P . Wound healing in the 21st century. J Am Acad Dermatol. 2010; 63(5):866-81. DOI: 10.1016/j.jaad.2009.10.048. View

20.

Nogueira G, Rodas A, Leite C, Giles C, Higa O, Polakiewicz B . Preparation and characterization of ethanol-treated silk fibroin dense membranes for biomaterials application using waste silk fibers as raw material. Bioresour Technol. 2010; 101(21):8446-51. DOI: 10.1016/j.biortech.2010.06.064. View