Effects of Computer-assisted Navigation Versus the Conventional Technique for Total Knee Arthroplasty on Levels of Plasma Thrombotic Markers: a Prospective Study

Overview

Journal Biomed Eng Online

Publisher Biomed Central

Specialty Biomedical Engineering

Date 2019 Oct 16

PMID 31610791

Citations 3

Authors

Ka-Kit Siu

Kwan-Ting Wu

Jih-Yang Ko

Feng-Sheng Wang

Wen-Yi Chou

Ching-Jen Wang

Shu-Jui Kuo

Affiliations

Soon will be listed here.

Abstract

Background: Venous thromboembolism (VTE) is a major sequela after total knee arthroplasty (TKA). We prospectively compared the differences in the perioperative plasma D-dimer and fibrinogen levels between the individuals undergoing TKA via computer-assisted navigation and via a conventional method as the surrogate comparison for VTE. There were 174 patients fulfilling the inclusion criteria and providing valid informed consent between September 2011 and November 2013. There were 69 females and 20 males in the navigation-assisted group (median age: 71.00 years), while the conventional group was composed of 59 females and 26 males (median age: 69.00 years). Blood samples were obtained prior to and at 24 and 72 h after surgery for measurement of the levels of plasma D-dimer and fibrinogen.

Results: A significantly lower plasma D-dimer level 24 h after TKA (p = 0.001) and a milder postoperative surge 24 h after TKA (p = 0.002) were observed in patients undergoing navigation-assisted TKA. The proportions of subjects exceeding the plasma D-dimer cut-off values of 7.5, 8.6 and 10 mg/L 24 h after TKA were all significantly higher in the conventional group than in the navigation-assisted group (p = 0.024, 0.004, and 0.004, respectively).

Conclusions: A lower plasma D-dimer level and a milder surge in the plasma D-dimer level were observed in patients undergoing navigation-assisted TKA in comparison with patients undergoing conventional TKA 24 h after surgery. These findings may supplement the known advantages of navigation-assisted TKA.

Citing Articles

The Differential Systemic Biological Effects between Computer Navigation and Conventional Total Knee Arthroplasty (TKA) Surgeries: A Prospective Study.

Kuo S, Siu K, Wu K, Ko J, Wang F J Pers Med. 2022; 12(11).

PMID: 36579565 PMC: 9696737. DOI: 10.3390/jpm12111835.

After 25 years of computer-navigated total knee arthroplasty, where do we stand today?.

Shah S Arthroplasty. 2022; 3(1):41.

PMID: 35236503 PMC: 8796491. DOI: 10.1186/s42836-021-00100-9.

Resistin Enhances VCAM-1 Expression and Monocyte Adhesion in Human Osteoarthritis Synovial Fibroblasts by Inhibiting MiR-381 Expression through the PKC, p38, and JNK Signaling Pathways.

Chen W, Lin C, Kuo S, Liu S, Lu Y, Chen Y Cells. 2020; 9(6).

PMID: 32492888 PMC: 7349127. DOI: 10.3390/cells9061369.

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