SIRT1 in the Development and Treatment of Hepatocellular Carcinoma

Overview

Journal Front Nutr

Specialty Nutritional Sciences

Date 2019 Oct 15

PMID 31608282

Citations 24

Authors

Marius Farcas

Andrei-Alexandru Gavrea

Diana Gulei

Calin Ionescu

Alexandru Irimie

Cristina S Catana

Ioana Berindan-Neagoe

Affiliations

Soon will be listed here.

Abstract

Hepatocellular carcinoma (HCC) is one of the most common causes of cancer-related death worldwide. Current treatment options for inoperable HCCs have decreased therapeutic efficacy and are associated with systemic toxicity and chemoresistance. Sirtuin 1 (SIRT1) is a nicotinamide adenine dinucleotide-dependent enzyme that is frequently overexpressed in HCC, where it promotes tumorigenicity, metastasis, and chemoresistance. SIRT1 also maintains the tumorigenic and self-renewal proprieties of liver cancer stem cells. Multiple tumor-suppressive microRNAs (miRNAs) are downregulated in HCC and, as a consequence, permit SIRT1-induced tumorigenicity. However, either directly targeting SIRT1, combining conventional chemotherapy with SIRT1 inhibitors, or upregulating tumor-suppressive miRNAs may improve therapeutic efficacy and patient outcomes. Here, we present the interaction between SIRT1, miRNAs, and liver cancer stem cells and discuss the consequences of their interplay for the development and treatment of HCC.

Citing Articles

Involvement of SIRT1-mediated aging in liver diseases.

Zhang Y, Gong C, Tao L, Zhai J, Huang F, Zhang S Front Cell Dev Biol. 2025; 13:1548015.

PMID: 40052151 PMC: 11882576. DOI: 10.3389/fcell.2025.1548015.

The role of histone post-translational modifications in cancer and cancer immunity: functions, mechanisms and therapeutic implications.

Duan X, Xing Z, Qiao L, Qin S, Zhao X, Gong Y Front Immunol. 2024; 15:1495221.

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The role of SIRT1 in autophagy and drug resistance: unveiling new targets and potential biomarkers in cancer therapy.

Tang Y, Ju W, Liu Y, Deng Q Front Pharmacol. 2024; 15:1469830.

PMID: 39403142 PMC: 11471651. DOI: 10.3389/fphar.2024.1469830.

Targeting Hepatic Cancer Stem Cells (CSCs) and Related Drug Resistance by Small Interfering RNA (siRNA).

Jasim S, Omar Dheyauldeen Salahdin , Malathi H, Sharma N, Rab S, Aminov Z Cell Biochem Biophys. 2024; 82(4):3031-3051.

PMID: 39060914 DOI: 10.1007/s12013-024-01423-5.

The dual role of sirtuins in cancer: biological functions and implications.

Yu L, Li Y, Song S, Zhang Y, Wang Y, Wang H Front Oncol. 2024; 14:1384928.

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