Metagenomic Analysis Identified Pneumonia in an Infant Suffering From Unexplained Very Severe Pneumonia

Overview

Journal Front Pediatr

Specialty Pediatrics

Date 2019 Oct 15

PMID 31608265

Citations 8

Authors

Yan Lin

Bao-Xi Wang

Ni-Ni Zhang

Lei Zhang

Zhi-Bo Gao

Jiao Tian

Xun Jiang

Affiliations

Soon will be listed here.

Abstract

Pneumonia poses a significant global morbidity and mortality burden on children. Etiological diagnosis and matched anti-microbial therapy are particularly important for very severe pneumonia. Although great advances have been achieved in diagnostic approaches, it remains challenging to identify pathogens in unexplained pneumonia (UP) cases. In this study, we applied next-generation sequencing (NGS) technology and a metagenomic approach to detect and characterize respiratory bactiera in an UP case in infant. was the only bacterial pathogen detected in blood. Metagenomic sequencing also provided bacteria genomic sequences, which could be used to evaluate the role of this pathogen in the disease. This NGS method has the potential to improve the identification of causative organisms in patients with pneumonia and the delivery of appropriate, pathogen-directed antibiotic therapy.

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