Regenerative Medicine: Could Parkinson's Be the First Neurodegenerative Disease to Be Cured?

Overview

Journal Future Sci OA

Specialty Biotechnology

Date 2019 Oct 15

PMID 31608157

Citations 7

Authors

Mariacruz L Diaz

Affiliations

Soon will be listed here.

Abstract

Parkinson's disease is one of the most insidious neurodegenerative diseases in developed countries. Today, human pluripotent stem cells are produced from embryonic or adult cells, multiplied, differentiated into neural cell lines and ultimately transplanted into disease animal models or patients. Nowadays, DOPAminergic neurons derived from human pluripotent stem cells and human parthenogenetic cells are being clinically tested in China and Australia, respectively. More importantly, good manufacturing practices have been developed and the neurons obtained have been successfully tested in nonhuman primates by teams in Europe, USA and Japan. However, there is a need for translational clinical studies with small molecules tested , as well as testing of the the efficacy of additional therapies.

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