Understanding CD8 T Cell Immunity to Trypanosoma Cruzi and How to Improve It

Overview

Journal Trends Parasitol

Specialty Parasitology

Date 2019 Oct 15

PMID 31607632

Citations 23

Authors

Eva V Acosta Rodriguez

Cintia L Araujo Furlan

Facundo Fiocca Vernengo

Carolina L Montes

Adriana Gruppi

Affiliations

Soon will be listed here.

Abstract

The protozoan Trypanosoma cruzi is the causative agent of Chagas' disease, endemic in Latin America but present worldwide. Research efforts have focused on the examination of immune mechanisms that mediate host protection as well as immunopathology during this parasitic infection. The study of CD8 T cell immunity emerges as a key aspect given the critical importance of parasite-specific CD8 T cells for host resistance throughout the infection. In recent years, new research has shed light on novel pathways that modulate the induction, maintenance, and regulation of CD8 T cell responses to T. cruzi. This new knowledge is setting the ground for future vaccines and/or immunotherapies. Herein, we critically review and analyze the latest results published in the field.

Citing Articles

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CD39 expression by regulatory T cells participates in CD8+ T cell suppression during experimental Trypanosoma cruzi infection.

Araujo Furlan C, Boccardo S, Rodriguez C, Mary V, Gimenez C, Robson S PLoS Pathog. 2024; 20(4):e1012191.

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