Folate-receptor 1 Level in Periodontal Disease: a Pilot Study

Overview

Journal BMC Oral Health

Publisher Biomed Central

Specialty Dentistry

Date 2019 Oct 13

PMID 31604439

Citations 2

Authors

Duygu Alkan

Berrak Guven

Cigdem Coskun Turer

Umut Balli

Murat Can

Affiliations

Soon will be listed here.

Abstract

Background: The purpose of this study was to investigate gingival crevicular fluid (GCF) and serum folate-receptor 1 (FOLR1) levels in subjects with different periodontal status.

Methods: The study consists of three groups: Healthy group (n = 15), gingivitis group (n = 15) and chronic periodontitis group (n = 15). Clinical periodontal parameters including probing pocket depth (PPD), clinical attachment level (CAL), gingival index (GI) and bleeding on probing (BOP) were assessed. GCF and serum samples were collected from each patient and were analyzed FOLR1 levels by enzyme-linked immunosorbent assay.

Results: The values of FOLR1 in GCF were higher in gingivitis and periodontitis groups than among patient in control group (p < 0.016). Serum FOLR1 levels showed no significant difference between the groups. A significant correlation was observed between FOLR1 levels of GCF and BOP (p < 0.05).

Conclusions: Our preliminary data suggest that FOLR1 is not useful in monitoring the periodontal disease. Further studies are necessary to clarify the role, regulation and function of folate and it's receptors in the pathogenesis of periodontal disease.

Citing Articles

Red blood cell folate level is associated with periodontitis in American adults: results from the NHANES 2009-2014.

Liu Z, Luo S, Jiao R, Li W, Jin F, Sun J BMC Oral Health. 2024; 24(1):825.

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Nanophotosensitizers for Folate Receptor-Targeted and Redox-Sensitive Delivery of Chlorin E6 against Cancer Cells.

Kook M, Lee C, Jeong Y, Kim B Materials (Basel). 2020; 13(12).

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