Dose-volume Analysis of Predictors for Acute Anal Toxicity After Radiotherapy in Prostate Cancer Patients

Overview

Journal Radiat Oncol

Publisher Biomed Central

Specialties Oncology
Radiology

Date 2019 Oct 12

PMID 31601249

Citations 3

Authors

Xingsi Peng

Sha Zhou

Shiliang Liu

Jibin Li

Sijuan Huang

Xiaobo Jiang

Maosheng Lin

Shaomin Huang

Chengguang Lin

Chaonan Qian

Mengzhong Liu

Liru He

Affiliations

Soon will be listed here.

Abstract

Background: This study aimed to evaluate the clinical and dosimetric factors predictive of acute anal toxicity (AAT) after radiotherapy in prostate cancer (PCa) patients with or without hemorrhoids.

Methods: We analyzed data from 347 PCa patients (248 cases treated from July 2013 to November 2017 for training cohort and 99 cases treated in 2018 for validation cohort) treated with pelvic radiotherapy at a single institution. Anal canal dose-volume histogram was used to determine the prescribed dose. Univariate and multivariate analyses were used to evaluate the risk of AAT as a function of clinical and dosimetric factors.

Results: Totally, 39.5% (98/248) and 31.3% (31/99) of the PCa patients developed AAT in training and validation cohorts, respectively. The incidence of AAT was much higher in patients with hemorrhoids than in those without hemorrhoids in both training and validation cohorts. Hemorrhoids and volume received more than 20 Gy (V20) were valuated as independent factors for predicting AAT in training cohort. Similar results were also observed in our validation cohort. The combination of hemorrhoids and high anal canal V20 (> 74.93% as determined by ROC curves) showed the highest specificity and positive predictive values for predicting AAT in both training and validation cohorts.

Conclusions: AAT occurs commonly in PCa patients with hemorrhoids during and after pelvic radiotherapy. Hemorrhoids and anal canal V20 are independent predictors of AAT. These factors should be carefully considered during treatment planning to minimize the incidence of AAT.

Citing Articles

Dose-Volume Constraints fOr oRganS At risk In Radiotherapy (CORSAIR): An "All-in-One" Multicenter-Multidisciplinary Practical Summary.

Bisello S, Cilla S, Benini A, Cardano R, Nguyen N, Deodato F Curr Oncol. 2022; 29(10):7021-7050.

PMID: 36290829 PMC: 9600677. DOI: 10.3390/curroncol29100552.

Radiotherapy-Induced Digestive Injury: Diagnosis, Treatment and Mechanisms.

Chen G, Han Y, Zhang H, Tu W, Zhang S Front Oncol. 2021; 11:757973.

PMID: 34804953 PMC: 8604098. DOI: 10.3389/fonc.2021.757973.

Aggravation of Hemorrhoids in Patients With Cervical Cancer Undergoing Radiotherapy: A Nationwide Population-based Study.

Seo I, Jang H In Vivo. 2021; 35(4):2357-2361.

PMID: 34182518 PMC: 8286530. DOI: 10.21873/invivo.12512.

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