Application of Copper(i) Salt and Fluoride Promoted Stille Coupling Reactions in the Synthesis of Bioactive Molecules

Overview

Journal Org Biomol Chem

Publisher Royal Society of Chemistry

Specialties Biochemistry
Chemistry

Date 2019 Oct 10

PMID 31596305

Citations 6

Authors

Victor Lee

Affiliations

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Abstract

The Stille coupling between organostannanes and organohalides is an effective catalytic method for organic synthesis. Despite the ample amount of published results in this area, finding the optimal conditions for this transformation is often not straightforward. It was observed that this reaction could be accelerated with improved efficiency by the addition of a Cu(i) salt and fluoride. This review summarises the application of this simple protocol in the synthesis of natural products, their analogues and other biologically active molecules, from 2004 to 2018.

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