Controlled Delivery of Nitric Oxide for Cancer Therapy

Overview

Journal Pharm Nanotechnol

Specialties Biotechnology
Pharmacology

Date 2019 Oct 10

PMID 31595847

Citations 24

Authors

Houman Alimoradi

Khaled Greish

Allan B Gamble

Gregory I Giles

Affiliations

Soon will be listed here.

Abstract

Nitric oxide (NO) is a short-lived, endogenously produced, signaling molecule which plays multiple roles in mammalian physiology. Underproduction of NO is associated with several pathological processes; hence a broad range of NO donors have emerged as potential therapeutics for cardiovascular and respiratory disorders, wound healing, the immune response to infection, and cancer. However, short half-lives, chemical reactivity, rapid systemic clearance, and cytotoxicity have hindered the clinical development of most low molecular weight NO donors. Hence, for controlled NO delivery, there has been extensive effort to design novel NO-releasing biomaterials for tumor targeting. This review covers the effects of NO in cancer biology, NO releasing moieties which can be used for NO delivery, and current advances in the design of NO releasing biomaterials focusing on their applications for tumor therapy.

Citing Articles

Evaluation of Anticancer Activity of Nucleoside-Nitric Oxide Photo-Donor Hybrids.

Marchesi E, Melloni E, Casciano F, Pozza E, Argazzi R, De Risi C Molecules. 2024; 29(14).

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Spin Trapping of Nitric Oxide by Hemoglobin and Ferrous Diethyldithiocarbamate in Model Tumors Differing in Vascularization.

Szczygiel D, Szczygiel M, Las A, Elas M, Zuziak R, Plonka B Int J Mol Sci. 2024; 25(8).

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A novel multifunctional microneedle patch for synergistic photothermal- gas therapy against maxillofacial malignant melanoma and associated skin defects.

Dong S, Zhang Y, Zhang Y, Mei Y, Sina A, Zou R J Nanobiotechnology. 2024; 22(1):199.

PMID: 38654266 PMC: 11036725. DOI: 10.1186/s12951-024-02409-4.

Can Nitric Oxide-Based Therapy Be Improved for the Treatment of Cancers? A Perspective.

Sinha B Int J Mol Sci. 2023; 24(17).

PMID: 37686417 PMC: 10487592. DOI: 10.3390/ijms241713611.

Nosip is a potential therapeutic target in hepatocellular carcinoma cells.

Gao J, Yang D, Huang Z, Pan X, Cao R, Lian C iScience. 2023; 26(8):107353.

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