Vaccination Management of Beef Cattle: Delayed Vaccination and Endotoxin Stacking

Overview

Journal Vet Clin North Am Food Anim Pract

Specialty Veterinary Medicine

Date 2019 Oct 9

PMID 31590903

Citations 15

Authors

John T Richeson

Heather D Hughes

Paul R Broadway

Jeffery A Carroll

Affiliations

Soon will be listed here.

Abstract

Vaccination is a critical component of cattle health management. Effective cattle vaccine programs should consider the timing of vaccination in relation to expected disease challenge, risk for wild-type exposure of various bovine pathogens, and host factors during vaccination. Nearly all consulting veterinarians recommend vaccination of stressed, high-risk calves on feedlot arrival. However, this recommendation fails to consider several factors associated with vaccine efficiency. Further research evaluating vaccine interactions in stressed cattle and potential additive effects of endotoxin from multiple bacterin administration may reveal new evidence-based vaccination guidelines for cattle in the various segments of beef and dairy production systems.

Citing Articles

Enzymic Activity, Metabolites, and Hematological Responses Changes of Clinical Healthy High-Risk Beef Calves During Their First 56-Days from Arrival.

Carrillo-Muro O, Hernandez-Briano P, Correa-Aguado P, Rivera-Villegas A, Sanchez-Barbosa O, Lazalde-Cruz R Animals (Basel). 2025; 15(2).

PMID: 39858133 PMC: 11758602. DOI: 10.3390/ani15020133.

A Systematic Review on the Impact of Vaccination for Respiratory Disease on Antibody Titer Responses, Health, and Performance in Beef and Dairy Cattle.

McAllister H, Ramirez B, Crews M, Rey L, Thompson A, Capik S Vet Sci. 2024; 11(12).

PMID: 39728939 PMC: 11680273. DOI: 10.3390/vetsci11120599.

Effects of vaccination and interventions on nasal microbiome and BRD-associated pathogens in calves.

Liu G, Zhang S, Xiang Z, Shirani I, Chen Y, Guo A Front Microbiol. 2024; 15:1467908.

PMID: 39624725 PMC: 11610248. DOI: 10.3389/fmicb.2024.1467908.

Enzymic Activity, Metabolites, and Hematological Responses in High-Risk Newly Received Calves for "Clinical Health" Reference Intervals.

Carrillo-Muro O, Rodriguez-Cordero D, Hernandez-Briano P, Correa-Aguado P, Medina-Flores C, Huerta-Lopez L Animals (Basel). 2024; 14(16).

PMID: 39199876 PMC: 11350765. DOI: 10.3390/ani14162342.

Integrated Blood Transcriptome and Multi-Tissue Trace Mineral Analyses of Healthy Stocker Cattle Fed Complexed or Inorganic Trace Mineral Supplement.

Scott M, Harvey K, Karisch B, Woolums A, Tracy R, Russell J Animals (Basel). 2024; 14(15).

PMID: 39123712 PMC: 11311009. DOI: 10.3390/ani14152186.

References

King M, Salman M, Wittum T, Odde K, Seeger J, Grotelueschen D . Effect of certified health programs on the sale price of beef calves marketed through a livestock videotape auction service from 1995 through 2005. J Am Vet Med Assoc. 2006; 229(9):1389-400. DOI: 10.2460/javma.229.9.1389. View

Nair G, Narain J . From endotoxin to exotoxin: De's rich legacy to cholera. Bull World Health Organ. 2010; 88(3):237-40. PMC: 2828792. DOI: 10.2471/BLT.09.072504. View

Bishop R . Fundamentals of endotoxin structure and function. Contrib Microbiol. 2004; 12:1-27. DOI: 10.1159/000081687. View

McSherry B, Horney F, DeGroot J . Plasma fibrinogen levels in normal and sick cows. Can J Comp Med. 1970; 34(3):191-7. PMC: 1319491. View

Waldner C, Jelinski M, McIntyre-Zimmer K . Survey of western Canadian beef producers regarding calf-hood diseases, management practices, and veterinary service usage. Can Vet J. 2013; 54(6):559-64. PMC: 3659451. View

Ives S, Richeson J . Use of Antimicrobial Metaphylaxis for the Control of Bovine Respiratory Disease in High-Risk Cattle. Vet Clin North Am Food Anim Pract. 2015; 31(3):341-50, v. DOI: 10.1016/j.cvfa.2015.05.008. View

Koch T, Duncker H, Axt R, SCHIEFER H, van Ackern K, NEUHOF H . Alterations of bacterial clearance induced by endotoxin and tumor necrosis factor. Infect Immun. 1993; 61(8):3143-8. PMC: 280981. DOI: 10.1128/iai.61.8.3143-3148.1993. View

Richeson J, Beck P, Gadberry M, Gunter S, Hess T, Hubbell 3rd D . Effects of on-arrival versus delayed modified live virus vaccination on health, performance, and serum infectious bovine rhinotracheitis titers of newly received beef calves. J Anim Sci. 2008; 86(4):999-1005. DOI: 10.2527/jas.2007-0593. View

Crosby H, Bion J, Penn C, Elliott T . Antibiotic-induced release of endotoxin from bacteria in vitro. J Med Microbiol. 1994; 40(1):23-30. DOI: 10.1099/00222615-40-1-23. View

10.

Ellis J, Yong C . Systemic adverse reactions in young Simmental calves following administration of a combination vaccine. Can Vet J. 1997; 38(1):45-7. PMC: 1576671. View

11.

Jones G, Lowes J . The systemic inflammatory response syndrome as a predictor of bacteraemia and outcome from sepsis. QJM. 1996; 89(7):515-22. DOI: 10.1093/qjmed/89.7.515. View

12.

Fike G, Simroth J, Thomson D, Schwandt E, Spare R, Tarpoff A . A survey of recommended practices made by veterinary practitioners to cow-calf operations in the United States and Canada. Prof Anim Sci. 2020; 33(6):716-728. PMC: 7147640. DOI: 10.15232/pas.2017-01642. View

13.

Richeson J, Carroll J, Burdick Sanchez N, May N, Hughes H, Roberts S . Dexamethasone treatment differentially alters viral shedding and the antibody and acute phase protein response after multivalent respiratory vaccination in beef steers. J Anim Sci. 2016; 94(8):3501-3509. DOI: 10.2527/jas.2016-0572. View

14.

Step D, Krehbiel C, DePra H, Cranston J, Fulton R, Kirkpatrick J . Effects of commingling beef calves from different sources and weaning protocols during a forty-two-day receiving period on performance and bovine respiratory disease. J Anim Sci. 2008; 86(11):3146-58. DOI: 10.2527/jas.2008-0883. View

15.

Taylor J, Fulton R, Lehenbauer T, Step D, Confer A . The epidemiology of bovine respiratory disease: What is the evidence for predisposing factors?. Can Vet J. 2011; 51(10):1095-102. PMC: 2942046. View

16.

Eckersall P, Conner J . Bovine and canine acute phase proteins. Vet Res Commun. 1988; 12(2-3):169-78. DOI: 10.1007/BF00362798. View

17.

Hughes H, Carroll J, Burdick Sanchez N, Richeson J . Natural variations in the stress and acute phase responses of cattle. Innate Immun. 2013; 20(8):888-96. DOI: 10.1177/1753425913508993. View

18.

von Jeney N, Gunther E, Jann K . Mitogenic stimulation of murine spleen cells: relation to susceptibility to Salmonella infection. Infect Immun. 1977; 15(1):26-33. PMC: 421325. DOI: 10.1128/iai.15.1.26-33.1977. View

19.

Takeda K, Kaisho T, Akira S . Toll-like receptors. Annu Rev Immunol. 2003; 21:335-76. DOI: 10.1146/annurev.immunol.21.120601.141126. View

20.

Griffin C, Scott J, Karisch B, Woolums A, Blanton J, Kaplan R . A randomized controlled trial to test the effect of on-arrival vaccination and deworming on stocker cattle health and growth performance. Bov Pract (Stillwater). 2019; 52(1):26-33. PMC: 6528666. View