Relationship of Serum Salusin Beta Levels with Coronary Slow Flow

Overview

Journal Anatol J Cardiol

Publisher Kare Publishing

Specialty Cardiology & Vascular Diseases

Date 2019 Oct 5

PMID 31584433

Citations 6

Authors

Aydin Akyuz

Fatma Aydin

Seref Alpsoy

Demet Ozkaramanli Gur

Savas Guzel

Affiliations

Soon will be listed here.

Abstract

Objective: The pathophysiology of coronary slow flow (CSF) has not been clarified. Salusin-β is released predominantly from the atheroma plaques and influences the pathophysiologic processes of atherosclerosis. Therefore, this study aimed to determine serum salusin-β levels in CSF and its correlation with CSF.

Methods: The study included 39 patients with CSF, and the control group (n=42) consisted of consecutive subjects with normal coronary arteriogram. We measured salusin-β and thrombolysis in myocardial infarction frame count (TFC).

Results: Age, body mass index (BMI), systolic blood pressure, diabetes, hyperlipidemia, and smoking rates were similar (p values>0.05) in both groups. High sensitive C-reactive protein (2.80±1.2 vs. 2.21±1.2 mg/dL, p=0.011), salusin-β [1205 (330-2092) vs. 162 (29-676), pg/ml, p<0.001], corrected TFC of left anterior descending coronary artery (29±9 vs. 19.7±3.7, p<0.001), circumflex artery TFC (25±10 vs. 15±3.2, p<0.001), right coronary artery TFC (28±7.1 vs. 13±3.3, p<0.001), and mean TFC (28±4.4 vs. 16±3.7, p<0.001) were significantly higher in the CSF group. In univariate and multivariate regression analysis, only BMI (unstandardized β±SE=0.178±0.08, p=0.036) and salusin-β levels (unstandardized β±SE=0.006±0.01, p<0.001) were determined as predictors of CSF. There was a good correlation between serum salusin-β and mean TFC values (r=0.564; p<0.001).

Conclusion: There is an association between serum salusin-β levels and CSF.

Citing Articles

Emerging Predictors by Non-HDL-C/HDL-C Ratio and Novel Biomarkers for Coronary Slow Flow Phenomenon.

Vairaperumal T, Tsai Z, Liu P Acta Cardiol Sin. 2024; 40(4):367-372.

PMID: 39045366 PMC: 11261357. DOI: 10.6515/ACS.202407_40(4).20240624A.

The effect of coronary slow flow on left atrial structure and function.

Shui Z, Wang Y, Sun M, Gao Y, Liang S, Wang Y Sci Rep. 2021; 11(1):7511.

PMID: 33820937 PMC: 8021584. DOI: 10.1038/s41598-021-87193-z.

Author`s Reply.

Akyuz A, Aydin F, Alpsoy S, Ozkaramanli Gur D, Guzel S Anatol J Cardiol. 2020; 23(2):117.

PMID: 32011332 PMC: 7040879.

Salusin beta, atherosclerosis, and coronary slow flow.

Akinci S, Coner A Anatol J Cardiol. 2020; 23(2):117.

PMID: 32011318 PMC: 7040877. DOI: 10.14744/AnatolJCardiol.2019.11680.

Author`s Reply.

Akyuz A, Aydin F, Alpsoy S, Ozkaramanli Gur D, Guzel S Anatol J Cardiol. 2020; 23(1):57-58.

PMID: 31911573 PMC: 7141433.

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