The Prevalence of Polycystic Ovary Syndrome in Adolescents: A Systematic Review and Meta-analysis

Overview

Journal Int J Reprod Biomed

Specialty Reproductive Medicine

Date 2019 Oct 5

PMID 31583370

Citations 56

Authors

Marzieh Saei Ghare Naz

Fahimeh Ramezani Tehrani

Hamid Alavi Majd

Fazlollah Ahmadi

Giti Ozgoli

Farzaneh Rashidi Fakari

Vida Ghasemi

Affiliations

Soon will be listed here.

Abstract

Background: Polycystic ovarian syndrome is an endocrine disorder with many complications. This syndrome is a growing concern among adolescents around the world, with varying reports of its prevalence in different parts of the world.

Objective: This study aimed to determine the prevalence of polycystic ovary syndrome in adolescents by a systematic review and meta-analysis.

Materials And Methods: In this study, a search for published articles with an English language limitation and without a time limit was done in different databases (Scopus, PubMed, and Web of Science, Emabse and Cochrane) in January 2019. The 12 studies that met the criteria for entering a qualitative assessment scale of 5 and higher were subjected to systematic review and meta-analysis. Egger and Begg's tests were used to check the publication bias. Data were analyzed with STATA software, version 11.1.

Results: Twelve studies were included for meta-analysis. The total number of participants in the study was 149,477. The average quality score of all studies was 8.67 (range: 5-10). The prevalence of polycystic ovarian syndrome in adolescents based on the Rotterdam criteria was 11.04% (95% CI: 6.84-16.09%), based on the National Institute of Health criteria, it was 3.39% (95% CI: 0.28-9.54%), and based on Androgen Excess and Polycystic Ovary Syndrome Society, it was 8.03% (95% CI: 6.24-10.01%).

Conclusion: The result of this study showed that there is a variation in the prevalence of PCOS in adolescents based on different criteria; we suggest more community-based studies among adolescences in different parts of the world.

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References

Williams R, Ong K, Dunger D . Polycystic ovarian syndrome during puberty and adolescence. Mol Cell Endocrinol. 2013; 373(1-2):61-7. DOI: 10.1016/j.mce.2013.01.005. View

. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS). Hum Reprod. 2003; 19(1):41-7. DOI: 10.1093/humrep/deh098. View

Ding T, Hardiman P, Petersen I, Wang F, Qu F, Baio G . The prevalence of polycystic ovary syndrome in reproductive-aged women of different ethnicity: a systematic review and meta-analysis. Oncotarget. 2017; 8(56):96351-96358. PMC: 5707105. DOI: 10.18632/oncotarget.19180. View

Azziz R, Carmina E, Dewailly D, Diamanti-Kandarakis E, Escobar-Morreale H, Futterweit W . Positions statement: criteria for defining polycystic ovary syndrome as a predominantly hyperandrogenic syndrome: an Androgen Excess Society guideline. J Clin Endocrinol Metab. 2006; 91(11):4237-45. DOI: 10.1210/jc.2006-0178. View

Witchel S, Oberfield S, Rosenfield R, Codner E, Bonny A, Ibanez L . The Diagnosis of Polycystic Ovary Syndrome during Adolescence. Horm Res Paediatr. 2015; . DOI: 10.1159/000375530. View

Asgharnia M, Mirblook F, Ahmad Soltani M . The Prevalence of Polycystic Ovary Syndrome (PCOS) in High School Students in Rasht in 2009 According to NIH Criteria. Int J Fertil Steril. 2014; 4(4):156-9. PMC: 4023501. View

Esmaeilzadeh S, Delavar M, Amiri M, Khafri S, Pasha N . Polycystic ovary syndrome in Iranian adolescents. Int J Adolesc Med Health. 2014; 26(4):559-65. DOI: 10.1515/ijamh-2013-0335. View

Bozdag G, Mumusoglu S, Zengin D, Karabulut E, Yildiz B . The prevalence and phenotypic features of polycystic ovary syndrome: a systematic review and meta-analysis. Hum Reprod. 2016; 31(12):2841-2855. DOI: 10.1093/humrep/dew218. View

Joshi B, Mukherjee S, Patil A, Purandare A, Chauhan S, Vaidya R . A cross-sectional study of polycystic ovarian syndrome among adolescent and young girls in Mumbai, India. Indian J Endocrinol Metab. 2014; 18(3):317-24. PMC: 4056129. DOI: 10.4103/2230-8210.131162. View

10.

Sharif E, Rahman S, Zia Y, Rizk N . The frequency of polycystic ovary syndrome in young reproductive females in Qatar. Int J Womens Health. 2016; 9:1-10. PMC: 5179205. DOI: 10.2147/IJWH.S120027. View

11.

Munn Z, Moola S, Riitano D, Lisy K . The development of a critical appraisal tool for use in systematic reviews addressing questions of prevalence. Int J Health Policy Manag. 2014; 3(3):123-8. PMC: 4154549. DOI: 10.15171/ijhpm.2014.71. View

12.

Bazarganipour F, Taghavi S, Montazeri A, Ahmadi F, Chaman R, Khosravi A . The impact of polycystic ovary syndrome on the health-related quality of life: A systematic review and meta-analysis. Iran J Reprod Med. 2015; 13(2):61-70. PMC: 4426142. View

13.

Rashidi H, Ramezani Tehrani F, Bahri Khomami M, Tohidi M, Azizi F . To what extent does the use of the Rotterdam criteria affect the prevalence of polycystic ovary syndrome? A community-based study from the Southwest of Iran. Eur J Obstet Gynecol Reprod Biol. 2014; 174:100-5. DOI: 10.1016/j.ejogrb.2013.12.018. View

14.

Roe A, Dokras A . The diagnosis of polycystic ovary syndrome in adolescents. Rev Obstet Gynecol. 2011; 4(2):45-51. PMC: 3218544. View

15.

Christensen S, Black M, Smith N, Martinez M, Jacobsen S, Porter A . Prevalence of polycystic ovary syndrome in adolescents. Fertil Steril. 2013; 100(2):470-7. PMC: 3813299. DOI: 10.1016/j.fertnstert.2013.04.001. View

16.

Mehrabian F, Khani B, Kelishadi R, Ghanbari E . The prevalence of polycystic ovary syndrome in Iranian women based on different diagnostic criteria. Endokrynol Pol. 2011; 62(3):238-42. View

17.

Driscoll D . Polycystic ovary syndrome in adolescence. Ann N Y Acad Sci. 2003; 997:49-55. DOI: 10.1196/annals.1290.006. View

18.

Franks S . Polycystic ovary syndrome in adolescents. Int J Obes (Lond). 2008; 32(7):1035-41. DOI: 10.1038/ijo.2008.61. View

19.

Pfeifer S, Kives S . Polycystic ovary syndrome in the adolescent. Obstet Gynecol Clin North Am. 2009; 36(1):129-52. DOI: 10.1016/j.ogc.2008.12.004. View

20.

Carmina E . Diagnosis of polycystic ovary syndrome: from NIH criteria to ESHRE-ASRM guidelines. Minerva Ginecol. 2004; 56(1):1-6. View