DKK2 Impairs Tumor Immunity Infiltration and Correlates with Poor Prognosis in Pancreatic Ductal Adenocarcinoma

Overview

Journal J Immunol Res

Publisher Wiley

Specialty Allergy & Immunology

Date 2019 Oct 5

PMID 31583260

Citations 8

Authors

Jianyu Yang

Yongsheng Jiang

Ruizhe He

Wei Liu

Minwei Yang

Lingye Tao

Xueliang Fu

Yang Shen

Jiao Li

Dejun Liu

Yanmiao Huo

Junfeng Zhang

Rong Hua

Zhigang Zhang

Yongwei Sun

Affiliations

Soon will be listed here.

Abstract

Pancreatic ductal adenocarcinoma (PDAC) remains one of the most devastating cancer types despite the improvement of modern medicine. In our present study, we found that dickkopf-related protein 2 (DKK2) shares a higher expression in PDAC compared with adjacent pancreas tissue in tissue microarray. In addition, an elevated expression of DKK2 predicts poorer prognosis of patients and positively correlated with poor tumor differentiation. Multivariate Cox regression analysis was also performed and confirmed that the expression of DKK2 is an independent prognostic factor in PDAC. A high expression of DKK2 correlates with cell migration and epithelial mesenchymal transition based on gene set enrichment analysis (GSEA) while knockdown of DKK2 in PDAC cells resulted in impaired cellular migration. Furthermore, GSEA predicts negative correlation between tumor immunity invasion and DKK2 expression. We then confirmed these results and demonstrated that a higher expression of DKK2 imparts the recruitment of CD8 T cells. Our work suggested that DKK2 imparts tumor immune evasion and is associated with poor prognosis in pancreatic ductal adenocarcinoma.

Citing Articles

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DKK2 promotes the progression of oral squamous cell carcinoma through the PI3K/AKT signaling pathway.

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Dickkopf proteins in pathological inflammatory diseases.

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