Relationship Between Working Hours and Probability to Take Alopecia Medicine Among Korean Male Workers: a 4-year Follow-up Study

Overview

Journal Ann Occup Environ Med

Specialty Environmental Health

Date 2019 Oct 5

PMID 31583103

Citations 1

Authors

Kyung-Hun Son

Byung-Seong Suh

Han-Seur Jeong

Min-Woo Nam

Hyunil Kim

Hyeong-Cheol Kim

Affiliations

Soon will be listed here.

Abstract

Background: Many studies have reported the negative effects of long working hours on various health problems. However, whether hair loss is associated with working hours has been rarely investigated so far. The main purpose of this study is to explore the relationship between long working hours and the development of alopecia among Korean male workers.

Methods: A total of 13,391 male workers not to take alopecia medicine in 2013 were followed up to see if they have alopecia medicine after 4 years, and that was used to confirm the alopecia development. Weekly working hours were categorized into three groups: reference working hours (RWH; < 40 hours/week), long working hours (LWH, 40-52 hours/week), and much longer working hours (MLWH; > 52 hours/week). Multiple logistic regression analyses were conducted to investigate the relationship between long working hours and the development of alopecia after adjusting age, marital status, education, monthly household income, smoking, and work schedule within strata of the covariates.

Results: Long working hours was significantly related to the development of alopecia. The adjusted odds ratios (ORs) for the development of alopecia were 1.57 (95% confidence interval [CI]: 1.21-2.05) for LWH group and 1.74 (95% CI: 1.23-2.47) for MLWH group relative to RWH group.

Conclusions: Our findings suggest that unintentional development of alopecia is another potential health consequence of long working hours among Korean male workers. Preventive interventions to promote appropriate and reasonable working hours are required in our society.

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References

Yoon J, Jung P, Roh J, Seok H, Won J . Relationship between Long Working Hours and Suicidal Thoughts: Nationwide Data from the 4th and 5th Korean National Health and Nutrition Examination Survey. PLoS One. 2015; 10(6):e0129142. PMC: 4469698. DOI: 10.1371/journal.pone.0129142. View

Arck P, Handjiski B, Peters E, Peter A, Hagen E, Fischer A . Stress inhibits hair growth in mice by induction of premature catagen development and deleterious perifollicular inflammatory events via neuropeptide substance P-dependent pathways. Am J Pathol. 2003; 162(3):803-14. PMC: 1868104. DOI: 10.1016/S0002-9440(10)63877-1. View

Ford C, WENTZ D . Internship: what is stressful?. South Med J. 1986; 79(5):595-9. DOI: 10.1097/00007611-198605000-00019. View

Peters E, Hansen M, Overall R, Nakamura M, Pertile P, Klapp B . Control of human hair growth by neurotrophins: brain-derived neurotrophic factor inhibits hair shaft elongation, induces catagen, and stimulates follicular transforming growth factor beta2 expression. J Invest Dermatol. 2005; 124(4):675-85. DOI: 10.1111/j.0022-202X.2005.23648.x. View

Virtanen M, Ferrie J, Singh-Manoux A, Shipley M, Stansfeld S, Marmot M . Long working hours and symptoms of anxiety and depression: a 5-year follow-up of the Whitehall II study. Psychol Med. 2011; 41(12):2485-94. PMC: 3095591. DOI: 10.1017/S0033291711000171. View

Raediker B, Janssen D, Schomann C, Nachreiner F . Extended working hours and health. Chronobiol Int. 2006; 23(6):1305-16. DOI: 10.1080/07420520601096245. View

Brauner G, Goodheart H . Dermatologic care behind bars. J Am Acad Dermatol. 1988; 18(5 Pt 1):1066-73. DOI: 10.1016/s0190-9622(88)70107-3. View

Arck P, Slominski A, Theoharides T, Peters E, Paus R . Neuroimmunology of stress: skin takes center stage. J Invest Dermatol. 2006; 126(8):1697-704. PMC: 2232898. DOI: 10.1038/sj.jid.5700104. View

Huang M, Pang X, Karalis K, Theoharides T . Stress-induced interleukin-6 release in mice is mast cell-dependent and more pronounced in Apolipoprotein E knockout mice. Cardiovasc Res. 2003; 59(1):241-9. DOI: 10.1016/s0008-6363(03)00340-7. View

10.

Schmidt-Ullrich R, Paus R . Molecular principles of hair follicle induction and morphogenesis. Bioessays. 2005; 27(3):247-61. DOI: 10.1002/bies.20184. View

11.

Shields M . Long working hours and health. Health Rep. 2000; 11(2):33-48(Eng); 37-55(Fre). View

12.

Cash T . The psychological effects of androgenetic alopecia in men. J Am Acad Dermatol. 1992; 26(6):926-31. DOI: 10.1016/0190-9622(92)70134-2. View

13.

Peters E, Handjiski B, Kuhlmei A, Hagen E, Bielas H, Braun A . Neurogenic inflammation in stress-induced termination of murine hair growth is promoted by nerve growth factor. Am J Pathol. 2004; 165(1):259-71. PMC: 1618553. DOI: 10.1016/S0002-9440(10)63294-4. View

14.

Maruyama S, Kohno K, Morimoto K . [A study of preventive medicine in relation to mental health among middle-management employees (Part 2)--effects of long working hours on lifestyles, perceived stress and working-life satisfaction among white-collar middle-management employees]. Nihon Eiseigaku Zasshi. 1995; 50(4):849-60. DOI: 10.1265/jjh.50.849. View

15.

Hadshiew I, Foitzik K, Arck P, Paus R . Burden of hair loss: stress and the underestimated psychosocial impact of telogen effluvium and androgenetic alopecia. J Invest Dermatol. 2004; 123(3):455-7. DOI: 10.1111/j.0022-202X.2004.23237.x. View

16.

Bannai A, Tamakoshi A . The association between long working hours and health: a systematic review of epidemiological evidence. Scand J Work Environ Health. 2013; 40(1):5-18. DOI: 10.5271/sjweh.3388. View

17.

Botchkarev V, Metz M, Botchkareva N, Welker P, Lommatzsch M, Renz H . Brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 act as "epitheliotrophins" in murine skin. Lab Invest. 1999; 79(5):557-72. View

18.

Peters E, Hendrix S, Golz G, Klapp B, Arck P, Paus R . Nerve growth factor and its precursor differentially regulate hair cycle progression in mice. J Histochem Cytochem. 2005; 54(3):275-88. DOI: 10.1369/jhc.4A6585.2005. View

19.

Virtanen M, Ferrie J, Gimeno D, Vahtera J, Elovainio M, Singh-Manoux A . Long working hours and sleep disturbances: the Whitehall II prospective cohort study. Sleep. 2009; 32(6):737-45. PMC: 2690560. DOI: 10.1093/sleep/32.6.737. View

20.

Kim I, Kim H, Lim S, Lee M, Bahk J, June K . Working hours and depressive symptomatology among full-time employees: Results from the fourth Korean National Health and Nutrition Examination Survey (2007-2009). Scand J Work Environ Health. 2013; 39(5):515-20. DOI: 10.5271/sjweh.3356. View