What's in the Bag? Analysis of Exterior Drug Packaging by TD-DART-MS to Predict the Contents

Overview

Journal Forensic Sci Int

Specialty Forensic Sciences

Date 2019 Oct 4

PMID 31580981

Citations 7

Authors

Edward Sisco

Elizabeth L Robinson

Amber Burns

Rebecca Mead

Affiliations

Soon will be listed here.

Abstract

The need for a safe and reliable presumptive test for law enforcement, first responders, and laboratory personnel is critical in the era of dangerous synthetic opioids and other novel psychoactive substances. Obtaining drug identification information without handling bulk powder is one way of accomplishing this task. This work evaluates whether trace residue on the exterior of drug packaging presents a potential source for presumptive testing. Utilizing a wipe-based approach, the outside of the packaging of nearly 200 case exhibits were sampled and analyzed by thermal desorption direct analysis in real time mass spectrometry (TD-DART-MS). While residue on the law enforcement (outer) packaging was a poor indicator of the contents (less than 50% accurate), the exterior of the drug (inner) packaging was shown to be an excellent indicator of its contents (92% accurate). Quantitative analysis of the wipes, using liquid chromatography mass spectrometry (LC-MS/MS) showed that typical masses of residue on the exterior of packaging ranged from single to tens of micrograms - enough for detection by a number of trace detection tools. These initial results demonstrate that wipe-based trace sampling approaches present a promising, reliable, and safe method for presumptive testing by law enforcement, first responders, or laboratory personnel.

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References

Keller T, Miki A, Regenscheit P, Dirnhofer R, Schneider A, Tsuchihashi H . Detection of designer drugs in human hair by ion mobility spectrometry (IMS). Forensic Sci Int. 1998; 94(1-2):55-63. DOI: 10.1016/s0379-0738(98)00051-6. View

Olds W, Jaatinen E, Fredericks P, Cletus B, Panayiotou H, Izake E . Spatially offset Raman spectroscopy (SORS) for the analysis and detection of packaged pharmaceuticals and concealed drugs. Forensic Sci Int. 2011; 212(1-3):69-77. DOI: 10.1016/j.forsciint.2011.05.016. View

Armenta S, Garrigues S, de la Guardia M, Brassier J, Alcala M, Blanco M . Detection and characterization of emerging psychoactive substances by ion mobility spectrometry. Drug Test Anal. 2014; 7(4):280-9. DOI: 10.1002/dta.1678. View

de Veij M, Deneckere A, Vandenabeele P, de Kaste D, Moens L . Detection of counterfeit Viagra with Raman spectroscopy. J Pharm Biomed Anal. 2007; 46(2):303-9. DOI: 10.1016/j.jpba.2007.10.021. View

Coelho Neto J . Rapid detection of NBOME's and other NPS on blotter papers by direct ATR-FTIR spectrometry. Forensic Sci Int. 2015; 252:87-92. DOI: 10.1016/j.forsciint.2015.04.025. View

Cecinato A, Balducci C, Nervegna G . Occurrence of cocaine in the air of the World's cities. An emerging problem? A new tool to investigate the social incidence of drugs?. Sci Total Environ. 2008; 407(5):1683-90. DOI: 10.1016/j.scitotenv.2008.11.004. View

Leary P, Dobson G, Reffner J . Development and Applications of Portable Gas Chromatography-Mass Spectrometry for Emergency Responders, the Military, and Law-Enforcement Organizations. Appl Spectrosc. 2016; 70(5):888-96. DOI: 10.1177/0003702816638294. View

Sisco E, Verkouteren J, Staymates J, Lawrence J . Rapid detection of fentanyl, fentanyl analogues, and opioids for on-site or laboratory based drug seizure screening using thermal desorption DART-MS and ion mobility spectrometry. Forensic Chem. 2017; 4:108-115. PMC: 5731661. DOI: 10.1016/j.forc.2017.04.001. View

Lawton Z, Traub A, Fatigante W, Mancias J, OLeary A, Hall S . Analytical Validation of a Portable Mass Spectrometer Featuring Interchangeable, Ambient Ionization Sources for High Throughput Forensic Evidence Screening. J Am Soc Mass Spectrom. 2016; 28(6):1048-1059. DOI: 10.1007/s13361-016-1562-2. View

10.

Doran G, Deans R, De Filippis C, Kostakis C, Howitt J . The presence of licit and illicit drugs in police stations and their implications for workplace drug testing. Forensic Sci Int. 2017; 278:125-136. DOI: 10.1016/j.forsciint.2017.06.034. View

11.

Sisco E, Najarro M, Burns A . A snapshot of drug background levels on surfaces in a forensic laboratory. Forensic Chem. 2019; 11. PMC: 6760002. DOI: 10.1016/j.forc.2018.09.001. View

12.

Sisco E, Forbes T, Staymates M, Gillen G . Rapid Analysis of Trace Drugs and Metabolites Using a Thermal Desorption DART-MS Configuration. Anal Methods. 2017; 8(35):6494-6499. PMC: 5473286. DOI: 10.1039/C6AY01851C. View

13.

Angelini D, Biggs T, Maughan M, Feasel M, Sisco E, Sekowski J . Evaluation of a lateral flow immunoassay for the detection of the synthetic opioid fentanyl. Forensic Sci Int. 2019; 300:75-81. PMC: 6956851. DOI: 10.1016/j.forsciint.2019.04.019. View

14.

Materazzi S, Gregori A, Ripani L, Apriceno A, Risoluti R . Cocaine profiling: Implementation of a predictive model by ATR-FTIR coupled with chemometrics in forensic chemistry. Talanta. 2017; 166:328-335. DOI: 10.1016/j.talanta.2017.01.045. View

15.

Cecinato A, Balducci C . Detection of cocaine in the airborne particles of the Italian cities Rome and Taranto. J Sep Sci. 2007; 30(12):1930-5. DOI: 10.1002/jssc.200700039. View