MTNR1B Genetic Polymorphisms As Risk Factors for Gestational Diabetes Mellitus: a Case-control Study in a Single Tertiary Care Center

Overview

Journal Ann Saudi Med

Specialty General Medicine

Date 2019 Oct 4

PMID 31580701

Citations 17

Authors

Khalid Khalaf Alharbi

Abdulrahman Mohammed Al-Sulaiman

Khalid Muath Bin Shedaid

Ali M Al-Shangiti

Mohammed Marie

Yazeed A Al-Sheikh

Imran Ali Khan

Affiliations

Soon will be listed here.

Abstract

Background: Gestational diabetes mellitus (GDM) is a metabolic disease in pregnancy that causes carbohydrate intolerance and hyper-glycemia. Genome-wide association studies and meta-analyses have found that the single nucleotide polymorphisms (SNPs) rs1387153 and rs10830963 of the melatonin receptor 1B ( MTNR1B) gene are associated with GDM. No studies on the MTNR1B gene effect on GDM have been performed in Saudis, other Arabs, or other Middle Eastern populations.

Objectives: Investigate the association of genotype or allele frequencies of the two SNPs with GDM and with clinical parameters related to GDM.

Design: Case-control study.

Settings: Tertiary care center, Riyadh.

Patients And Methods: We recruited 400 pregnant Saudi women ages 18-45 years (200 were diagnosed with GDM, and 200 were healthy controls). Biochemical assays were performed, and rs1387153 and rs10830963 polymorphisms were analyzed by polymerase chain reaction-restriction fragment length polymorphism analysis and real-time polymerase chain reaction with TaqMan genotyping.

Main Outcome Measures: The association of MTNR1B gene (rs1387153 and rs10830963 polymorphisms) with GDM and with biochemical parameters related to GDM.

Sample Size: 200 GDM cases and 200 non-GDM controls.

Results: Differences in allele frequencies for GDM vs non-GMD were statistically significant or nearly significant for both SNPs after adjustment for age and body mass index. In a logistic regression analysis, genotype TT was positively associated with post-prandial blood glucose (P=.018), but other associations were not statistically significant.

Conclusion: The odds ratios for the associations between the rs1387153 and rs10830963 SNPs and GDM exceeded 1.5-fold, which is higher than typically reported for diseases with complex genetic background. These effect sizes for GDM suggest pregnancy-specific factors related to the MTNR1B risk genotypes.

Limitations: Only two SNPs were studied.

Conflict Of Interest: None.

Citing Articles

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Liu J, Li W, Liu B, Dai A, Wang Y, She L Diabetes Metab Syndr Obes. 2022; 15:1207-1216.

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Wu Q, Chen Y, Zhou M, Liu M, Zhang L, Liang Z Diabetol Metab Syndr. 2022; 14(1):15.

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