Subjective Swallowing Symptoms and Related Risk Factors in COPD

Overview

Journal ERJ Open Res

Specialty Pulmonary Medicine

Date 2019 Oct 4

PMID 31579679

Citations 2

Authors

Margareta Gonzalez Lindh

Andrei Malinovschi

Eva Branden

Christer Janson

Bjorn Stallberg

Kristina Broms

Monica Blom Johansson

Karin Lisspers

Hirsh Koyi

Affiliations

Soon will be listed here.

Abstract

Objectives: This study aimed to investigate the prevalence of subjective ( self-reported) swallowing symptoms in a large cohort of patients with stable chronic obstructive pulmonary disease (COPD) and to identify potential related risk factors.

Methods: A total of 571 patients with COPD, investigated in a stable phase, participated in this multicentre study (335 females, 236 males; mean age: 68.6 years (sd 7.7)). Data were derived from spirometry, a questionnaire and a 30-metre walking test.

Results: In total, 33% (n=186) patients reported at least some degree of swallowing problem. The most frequently reported symptom was food lodging in the throat (23%). A significant relationship was found between swallowing symptoms and dyspnoea, assessed as modified Medical Research Council (mMRC) ≥2 compared with <2 (46% 22%; p<0.001) and health-related quality of life, assessed as the COPD Assessment Test (CAT) ≥10 (40% 19%; p<0.001). Swallowing problems were also related to lower physical capacity (p=0.02) but not to lung function (p>0.28).

Conclusion: Subjective swallowing symptoms seem to be a common problem in patients with stable COPD. This problem is seen in all stages of the disease, but is more common in symptomatic patients and in patients with lower physical capacity.

Citing Articles

Study on predictive models for swallowing risk in patients with AECOPD.

Xiong S, Zhou Y, He W, Zhu J, He W, Ding M BMC Pulm Med. 2024; 24(1):95.

PMID: 38395811 PMC: 10893668. DOI: 10.1186/s12890-024-02908-y.

Swallowing dysfunction in patients hospitalised due to a COPD exacerbation.

Lindh M, Janson C, Blom Johansson M, Jonsson M, Malberg E, Allansson E ERJ Open Res. 2021; 7(2).

PMID: 34109239 PMC: 8181655. DOI: 10.1183/23120541.00173-2021.

References

Kertscher B, Speyer R, Fong E, Georgiou A, Smith M . Prevalence of oropharyngeal dysphagia in the Netherlands: a telephone survey. Dysphagia. 2014; 30(2):114-20. DOI: 10.1007/s00455-014-9584-z. View

Mann G, Hankey G, Cameron D . Swallowing function after stroke: prognosis and prognostic factors at 6 months. Stroke. 1999; 30(4):744-8. DOI: 10.1161/01.str.30.4.744. View

Lindh M, Blom Johansson M, Jennische M, Koyi H . Prevalence of swallowing dysfunction screened in Swedish cohort of COPD patients. Int J Chron Obstruct Pulmon Dis. 2017; 12:331-337. PMC: 5261551. DOI: 10.2147/COPD.S120207. View

Martin-Harris B, Brodsky M, Michel Y, Ford C, Walters B, Heffner J . Breathing and swallowing dynamics across the adult lifespan. Arch Otolaryngol Head Neck Surg. 2005; 131(9):762-70. DOI: 10.1001/archotol.131.9.762. View

Ickenstein G, Riecker A, Hohlig C, Muller R, Becker U, Reichmann H . Pneumonia and in-hospital mortality in the context of neurogenic oropharyngeal dysphagia (NOD) in stroke and a new NOD step-wise concept. J Neurol. 2010; 257(9):1492-9. PMC: 2927734. DOI: 10.1007/s00415-010-5558-8. View

Berglund E, BIRATH G, Bjure J, Grimby G, Kjellmer I, Sandqvist L . Spirometric studies in normal subjects. I. Forced expirograms in subjects between 7 and 70 years of age. Acta Med Scand. 1963; 173:185-92. View

Bestall J, Paul E, Garrod R, Garnham R, Jones P, Wedzicha J . Usefulness of the Medical Research Council (MRC) dyspnoea scale as a measure of disability in patients with chronic obstructive pulmonary disease. Thorax. 1999; 54(7):581-6. PMC: 1745516. DOI: 10.1136/thx.54.7.581. View

Ghannouchi I, Speyer R, Doma K, Cordier R, Verin E . Swallowing function and chronic respiratory diseases: Systematic review. Respir Med. 2016; 117:54-64. DOI: 10.1016/j.rmed.2016.05.024. View

Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V . Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet. 2012; 380(9859):2095-128. PMC: 10790329. DOI: 10.1016/S0140-6736(12)61728-0. View

10.

Theander K, Hasselgren M, Luhr K, Eckerblad J, Unosson M, Karlsson I . Symptoms and impact of symptoms on function and health in patients with chronic obstructive pulmonary disease and chronic heart failure in primary health care. Int J Chron Obstruct Pulmon Dis. 2014; 9:785-94. PMC: 4111648. DOI: 10.2147/COPD.S62563. View

11.

Miravitlles M, Ribera A . Understanding the impact of symptoms on the burden of COPD. Respir Res. 2017; 18(1):67. PMC: 5399825. DOI: 10.1186/s12931-017-0548-3. View

12.

Sundh J, Janson C, Johansson G, Linden A, Lofdahl C, Sandstrom T . Characterization of secondary care for COPD in Sweden. Eur Clin Respir J. 2017; 4(1):1270079. PMC: 5328327. DOI: 10.1080/20018525.2016.1270079. View

13.

Zheng Z, Wu Z, Liu N, Chen P, Hou P, Wang X . Silent aspiration in patients with exacerbation of COPD. Eur Respir J. 2016; 48(2):570-3. DOI: 10.1183/13993003.00007-2016. View

14.

Cichero J, Altman K . Definition, prevalence and burden of oropharyngeal dysphagia: a serious problem among older adults worldwide and the impact on prognosis and hospital resources. Nestle Nutr Inst Workshop Ser. 2012; 72:1-11. DOI: 10.1159/000339974. View

15.

Kruis A, Stallberg B, Jones R, Tsiligianni I, Lisspers K, van der Molen T . Primary care COPD patients compared with large pharmaceutically-sponsored COPD studies: an UNLOCK validation study. PLoS One. 2014; 9(3):e90145. PMC: 3943905. DOI: 10.1371/journal.pone.0090145. View

16.

Stein M, Williams A, Grossman F, Weinberg A, Zuckerbraun L . Cricopharyngeal dysfunction in chronic obstructive pulmonary disease. Chest. 1990; 97(2):347-52. DOI: 10.1378/chest.97.2.347. View

17.

Clayton N, Carnaby G, Peters M, Ing A . Impaired laryngopharyngeal sensitivity in patients with COPD: the association with swallow function. Int J Speech Lang Pathol. 2014; 16(6):615-23. DOI: 10.3109/17549507.2014.882987. View

18.

Cabre M, Serra-Prat M, Palomera E, Almirall J, Pallares R, Clave P . Prevalence and prognostic implications of dysphagia in elderly patients with pneumonia. Age Ageing. 2009; 39(1):39-45. DOI: 10.1093/ageing/afp100. View

19.

Cvejic L, Harding R, Churchward T, Turton A, Finlay P, Massey D . Laryngeal penetration and aspiration in individuals with stable COPD. Respirology. 2010; 16(2):269-75. DOI: 10.1111/j.1440-1843.2010.01875.x. View

20.

Mannino D, Higuchi K, Yu T, Zhou H, Li Y, Tian H . Economic Burden of COPD in the Presence of Comorbidities. Chest. 2015; 148(1):138-150. PMC: 4493870. DOI: 10.1378/chest.14-2434. View