The Role of Microvesicles Containing MicroRNAs in Vascular Endothelial Dysfunction

Overview

Journal J Cell Mol Med

Specialties Cell Biology
Molecular Biology

Date 2019 Oct 3

PMID 31576661

Citations 36

Authors

Zeyu Shu

Jin Tan

Yuyang Miao

Qiang Zhang

Affiliations

Soon will be listed here.

Abstract

Many studies have shown that endothelial dysfunction is associated with a variety of cardiovascular diseases. The endothelium is one of the primary targets of circulating microvesicles. Besides, microRNAs emerge as important regulators of endothelial cell function. As a delivery system of microRNAs, microvesicles play an active and important role in regulating vascular endothelial function. In recent years, some studies have shown that microvesicles containing microRNAs regulate the pathophysiological changes in vascular endothelium, such as cell apoptosis, proliferation, migration and inflammation. These studies have provided some clues for the possible roles of microvesicles and microRNAs in vascular endothelial dysfunction-associated diseases, and opened the door towards discovering potential novel therapeutic targets. In this review, we provide an overview of the main characteristics of microvesicles and microRNAs, summarizing their potential role and mechanism in endothelial dysfunction, and discussing the clinical application and existing problems of microvesicles for better translational applications.

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