Coupled Biosynthesis of Cordycepin and Pentostatin in : Implications for Fungal Biology and Medicinal Natural Products

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2019 Oct 3

PMID 31576294

Citations 2

Authors

Peter A D Wellham

Dong-Hyun Kim

Matthias Brock

Cornelia H de Moor

Affiliations

Soon will be listed here.

Citing Articles

A Systematic Review of the Biological Effects of Cordycepin.

Radhi M, Ashraf S, Lawrence S, Tranholm A, Wellham P, Hafeez A Molecules. 2021; 26(19).

PMID: 34641429 PMC: 8510467. DOI: 10.3390/molecules26195886.

Culture Degeneration Reduces Sex-Related Gene Expression, Alters Metabolite Production and Reduces Insect Pathogenic Response in .

Wellham P, Hafeez A, Gregori A, Brock M, Kim D, Chandler D Microorganisms. 2021; 9(8).

PMID: 34442638 PMC: 8400478. DOI: 10.3390/microorganisms9081559.

References

Xia Y, Luo F, Shang Y, Chen P, Lu Y, Wang C . Fungal Cordycepin Biosynthesis Is Coupled with the Production of the Safeguard Molecule Pentostatin. Cell Chem Biol. 2017; 24(12):1479-1489.e4. DOI: 10.1016/j.chembiol.2017.09.001. View

Zhang P, Huang C, Fu C, Tian Y, Hu Y, Wang B . Cordycepin (3'-deoxyadenosine) suppressed HMGA2, Twist1 and ZEB1-dependent melanoma invasion and metastasis by targeting miR-33b. Oncotarget. 2015; 6(12):9834-53. PMC: 4496401. DOI: 10.18632/oncotarget.3383. View

Yang X, Li Y, He Y, Li T, Wang W, Zhang J . Cordycepin alleviates airway hyperreactivity in a murine model of asthma by attenuating the inflammatory process. Int Immunopharmacol. 2015; 26(2):401-8. DOI: 10.1016/j.intimp.2015.04.017. View

Ashraf S, Radhi M, Gowler P, Burston J, Gandhi R, Thorn G . The polyadenylation inhibitor cordycepin reduces pain, inflammation and joint pathology in rodent models of osteoarthritis. Sci Rep. 2019; 9(1):4696. PMC: 6423048. DOI: 10.1038/s41598-019-41140-1. View

Aramwit P, Porasuphatana S, Srichana T, Nakpheng T . Toxicity evaluation of cordycepin and its delivery system for sustained in vitro anti-lung cancer activity. Nanoscale Res Lett. 2015; 10:152. PMC: 4392036. DOI: 10.1186/s11671-015-0851-1. View

Nakamura K, Konoha K, Yoshikawa N, Yamaguchi Y, Kagota S, Shinozuka K . Effect of cordycepin (3'-deoxyadenosine) on hematogenic lung metastatic model mice. In Vivo. 2005; 19(1):137-41. View

Thomadaki H, Tsiapalis C, Scorilas A . The effect of the polyadenylation inhibitor cordycepin on human Molt-4 and Daudi leukaemia and lymphoma cell lines. Cancer Chemother Pharmacol. 2007; 61(4):703-11. DOI: 10.1007/s00280-007-0533-5. View

Kondrashov A, Meijer H, Barthet-Barateig A, Parker H, Khurshid A, Tessier S . Inhibition of polyadenylation reduces inflammatory gene induction. RNA. 2012; 18(12):2236-50. PMC: 3504674. DOI: 10.1261/rna.032391.112. View

Kim J, Yeon S, Kim H, Ahn Y . Larvicidal activity against Plutella xylostella of cordycepin from the fruiting body of Cordyceps militaris. Pest Manag Sci. 2002; 58(7):713-7. DOI: 10.1002/ps.508. View

10.

Kim H, Shrestha B, Lim S, Yoon D, Chang W, Shin D . Cordycepin inhibits lipopolysaccharide-induced inflammation by the suppression of NF-kappaB through Akt and p38 inhibition in RAW 264.7 macrophage cells. Eur J Pharmacol. 2006; 545(2-3):192-9. DOI: 10.1016/j.ejphar.2006.06.047. View

11.

Zhao Z, Song G, Tian H, Yu Y, Tian X, Liu J . Triacetyl-3-hydroxyphenyladenosine, a derivative of cordycepin, attenuates atherosclerosis in apolipoprotein E-knockout mice. Exp Biol Med (Maywood). 2012; 237(11):1262-72. DOI: 10.1258/ebm.2012.011401. View

12.

Huang L, Liang Y, Guo F, Zhou Z, Cheng B . Simultaneous separation and determination of active components in Cordyceps sinensis and Cordyceps militarris by LC/ESI-MS. J Pharm Biomed Anal. 2003; 33(5):1155-62. DOI: 10.1016/s0731-7085(03)00415-1. View

13.

Ren Z, Cui J, Huo Z, Xue J, Cui H, Luo B . Cordycepin suppresses TNF-α-induced NF-κB activation by reducing p65 transcriptional activity, inhibiting IκBα phosphorylation, and blocking IKKγ ubiquitination. Int Immunopharmacol. 2012; 14(4):698-703. DOI: 10.1016/j.intimp.2012.10.008. View

14.

Wang X, Xiang S, Li H, Wu X, Li M, Shu Y . Cordycepin induces S phase arrest and apoptosis in human gallbladder cancer cells. Molecules. 2014; 19(8):11350-65. PMC: 6271430. DOI: 10.3390/molecules190811350. View

15.

Kim H, Naura A, Errami Y, Ju J, Boulares A . Cordycepin blocks lung injury-associated inflammation and promotes BRCA1-deficient breast cancer cell killing by effectively inhibiting PARP. Mol Med. 2011; 17(9-10):893-900. PMC: 3188885. DOI: 10.2119/molmed.2011.00032. View

16.

Rosewich U, Kistler H . Role of Horizontal Gene Transfer in the Evolution of Fungi. Annu Rev Phytopathol. 2001; 38:325-363. DOI: 10.1146/annurev.phyto.38.1.325. View

17.

Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H . Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine. Cell Death Differ. 2011; 18(12):1876-88. PMC: 3214911. DOI: 10.1038/cdd.2011.63. View

18.

Vodnala S, Lundback T, Yeheskieli E, Sjoberg B, Gustavsson A, Svensson R . Structure-activity relationships of synthetic cordycepin analogues as experimental therapeutics for African trypanosomiasis. J Med Chem. 2013; 56(24):9861-73. DOI: 10.1021/jm401530a. View

19.

Rodman L, Farnell D, Coyne J, Allan P, Hill D, Duncan K . Toxicity of cordycepin in combination with the adenosine deaminase inhibitor 2'-deoxycoformycin in beagle dogs. Toxicol Appl Pharmacol. 1997; 147(1):39-45. DOI: 10.1006/taap.1997.8264. View

20.

Choi Y, Kim G, Lee H . Anti-inflammatory effects of cordycepin in lipopolysaccharide-stimulated RAW 264.7 macrophages through Toll-like receptor 4-mediated suppression of mitogen-activated protein kinases and NF-κB signaling pathways. Drug Des Devel Ther. 2014; 8:1941-53. PMC: 4206205. DOI: 10.2147/DDDT.S71957. View