Effects of Loratadine, a Histamine H Receptor Antagonist, on the Skeletal System of Young Male Rats

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2019 Oct 3

PMID 31576110

Citations 6

Authors

Joanna Folwarczna

Natalia Konarek

Karolina Freier

Dawid Karbowniczek

Piotr Londzin

Aleksandra Janas

Affiliations

Soon will be listed here.

Abstract

Background: Histamine H receptor antagonists are widely used in the treatment of allergic diseases. H receptors are expressed on bone cells and histamine takes part in regulation of bone metabolism. Loratadine is often prescribed to children.

Purpose: The aim of the present study was to investigate the effects of loratadine on the skeletal system of young rats.

Material And Methods: Loratadine (0.5, 5, and 50 mg/kg p.o. daily) was administered for 4 weeks to male Wistar rats, 6-week-old at the start of the experiment. Bone mass, mass of bone mineral, calcium, and phosphorus content in the bone mineral of the tibia, femur, and L-4 vertebra, histomorphometric parameters of the femur, mechanical properties of the proximal tibial metaphysis, femoral diaphysis and femoral neck, and serum levels of bone turnover markers were examined.

Results: Loratadine at 0.5 and 5 mg/kg did not significantly affect the skeletal system of young rats. At 50 mg/kg, loratadine decreased the femoral length, increased content of calcium and phosphorus in the bone mineral of the vertebra, and tended to improve mechanical properties of the tibial metaphysis.

Conclusion: High-dose loratadine slightly but significantly affected development of the skeletal system in rapidly growing rats.

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