Host Single Nucleotide Polymorphisms Modulating Influenza A Virus Disease in Humans

Overview

Journal Pathogens

Date 2019 Oct 3

PMID 31574965

Citations 20

Authors

Aitor Nogales

Marta L DeDiego

Affiliations

Soon will be listed here.

Abstract

A large number of human genes associated with viral infections contain single nucleotide polymorphisms (SNPs), which represent a genetic variation caused by the change of a single nucleotide in the DNA sequence. SNPs are located in coding or non-coding genomic regions and can affect gene expression or protein function by different mechanisms. Furthermore, they have been linked to multiple human diseases, highlighting their medical relevance. Therefore, the identification and analysis of this kind of polymorphisms in the human genome has gained high importance in the research community, and an increasing number of studies have been published during the last years. As a consequence of this exhaustive exploration, an association between the presence of some specific SNPs and the susceptibility or severity of many infectious diseases in some risk population groups has been found. In this review, we discuss the relevance of SNPs that are important to understand the pathology derived from influenza A virus (IAV) infections in humans and the susceptibility of some individuals to suffer more severe symptoms. We also discuss the importance of SNPs for IAV vaccine effectiveness.

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References

Kenney A, Dowdle J, Bozzacco L, McMichael T, St Gelais C, Panfil A . Human Genetic Determinants of Viral Diseases. Annu Rev Genet. 2017; 51:241-263. PMC: 6038703. DOI: 10.1146/annurev-genet-120116-023425. View

Smith G, Vijaykrishna D, Bahl J, Lycett S, Worobey M, Pybus O . Origins and evolutionary genomics of the 2009 swine-origin H1N1 influenza A epidemic. Nature. 2009; 459(7250):1122-5. DOI: 10.1038/nature08182. View

Osterlund P, Pietila T, Veckman V, Kotenko S, Julkunen I . IFN regulatory factor family members differentially regulate the expression of type III IFN (IFN-lambda) genes. J Immunol. 2007; 179(6):3434-42. DOI: 10.4049/jimmunol.179.6.3434. View

Bui C, Chughtai A, Adam D, MacIntyre C . An overview of the epidemiology and emergence of influenza A infection in humans over time. Arch Public Health. 2017; 75:15. PMC: 5366997. DOI: 10.1186/s13690-017-0182-z. View

Hidaka F, Matsuo S, Muta T, Takeshige K, Mizukami T, Nunoi H . A missense mutation of the Toll-like receptor 3 gene in a patient with influenza-associated encephalopathy. Clin Immunol. 2006; 119(2):188-94. DOI: 10.1016/j.clim.2006.01.005. View

Chen B, Leser G, Morita E, Lamb R . Influenza virus hemagglutinin and neuraminidase, but not the matrix protein, are required for assembly and budding of plasmid-derived virus-like particles. J Virol. 2007; 81(13):7111-23. PMC: 1933269. DOI: 10.1128/JVI.00361-07. View

Skevaki C, Pararas M, Kostelidou K, Tsakris A, Routsias J . Single nucleotide polymorphisms of Toll-like receptors and susceptibility to infectious diseases. Clin Exp Immunol. 2015; 180(2):165-77. PMC: 4408151. DOI: 10.1111/cei.12578. View

Zhang Y, Zhao Y, Li N, Peng Y, Giannoulatou E, Jin R . Interferon-induced transmembrane protein-3 genetic variant rs12252-C is associated with severe influenza in Chinese individuals. Nat Commun. 2013; 4:1418. PMC: 3562464. DOI: 10.1038/ncomms2433. View

Chang J, Lindsay R, Kulkarni S, Lifson J, Carrington M, Altfeld M . Polymorphisms in interferon regulatory factor 7 reduce interferon-α responses of plasmacytoid dendritic cells to HIV-1. AIDS. 2011; 25(5):715-7. PMC: 3098498. DOI: 10.1097/QAD.0b013e328343c186. View

10.

Ward A, Castelli L, Lucantoni A, White J, Azad A, Macreadie I . Expression and analysis of the NS2 protein of influenza A virus. Arch Virol. 1995; 140(11):2067-73. DOI: 10.1007/BF01322693. View

11.

Gao H, Sun H, Hu J, Qi L, Wang J, Xiong X . Twenty amino acids at the C-terminus of PA-X are associated with increased influenza A virus replication and pathogenicity. J Gen Virol. 2015; 96(8):2036-2049. PMC: 4681059. DOI: 10.1099/vir.0.000143. View

12.

Mathew S, Abdel-Hafiz H, Raza A, Fatima K, Qadri I . Host nucleotide polymorphism in hepatitis B virus-associated hepatocellular carcinoma. World J Hepatol. 2016; 8(10):485-98. PMC: 4820640. DOI: 10.4254/wjh.v8.i10.485. View

13.

Hu J, Mo Y, Gao Z, Wang X, Gu M, Liang Y . PA-X-associated early alleviation of the acute lung injury contributes to the attenuation of a highly pathogenic H5N1 avian influenza virus in mice. Med Microbiol Immunol. 2016; 205(4):381-95. PMC: 7086737. DOI: 10.1007/s00430-016-0461-2. View

14.

Wolff T, Ludwig S . Influenza viruses control the vertebrate type I interferon system: factors, mechanisms, and consequences. J Interferon Cytokine Res. 2009; 29(9):549-57. DOI: 10.1089/jir.2009.0066. View

15.

Rehman S, Rauf M, Abbas Z, Hamed M, Qadri I . Role of Some Predominant Host Immunomodulators' Single Nucleotide Polymorphisms in Severity of Hepatitis B Virus and Hepatitis C Virus Infection. Viral Immunol. 2016; 29(10):536-545. DOI: 10.1089/vim.2016.0062. View

16.

Leidner A, Murthy N, Chesson H, Biggerstaff M, Stoecker C, Harris A . Cost-effectiveness of adult vaccinations: A systematic review. Vaccine. 2018; 37(2):226-234. PMC: 6545890. DOI: 10.1016/j.vaccine.2018.11.056. View

17.

Lupfer C, Kanneganti T . The expanding role of NLRs in antiviral immunity. Immunol Rev. 2013; 255(1):13-24. PMC: 3759815. DOI: 10.1111/imr.12089. View

18.

Grohskopf L, Sokolow L, Broder K, Olsen S, Karron R, Jernigan D . Prevention and Control of Seasonal Influenza with Vaccines. MMWR Recomm Rep. 2016; 65(5):1-54. DOI: 10.15585/mmwr.rr6505a1. View

19.

Kim D, Song W . Membrane complement regulatory proteins. Clin Immunol. 2005; 118(2-3):127-36. DOI: 10.1016/j.clim.2005.10.014. View

20.

Everitt A, Clare S, Pertel T, John S, Wash R, Smith S . IFITM3 restricts the morbidity and mortality associated with influenza. Nature. 2012; 484(7395):519-23. PMC: 3648786. DOI: 10.1038/nature10921. View