Altered Brain Network Centrality in Patients with Late Monocular Blindness: a Resting-state FMRI Study

Overview

Journal Arch Med Sci

Specialty General Medicine

Date 2019 Oct 2

PMID 31572477

Citations 9

Authors

Xin Huang

Hai-Jun Li

De-Chang Peng

Lei Ye

Qi-Chen Yang

Yu-Lin Zhong

Fu-Qing Zhou

Yi Shao

Affiliations

Soon will be listed here.

Abstract

Introduction: The aim of the study was to investigate the underlying functional network brain activity changes in patients with late monocular blindness (MB) and the relationship with their clinical features using the voxel-wise degree centrality (DC) method.

Material And Methods: A total of 32 patients with MB (25 males and 7 females), and 32 healthy controls (HCs) (25 males and 7 females) closely matched in age, sex, and education, underwent resting-state functional magnetic resonance imaging scans. The DC method was used to assess local features of spontaneous brain activity. Correlation analysis was performed to explore the relationships between the observed mean signal values of the different areas and clinical features in these patients.

Results: Compared with HCs, MB patients had significantly lower values in the bilateral cuneus/V1/V2, and significantly higher values in the left inferior temporal gyrus and bilateral medial frontal gyrus. However, there was no relationship between the observed mean values of the different brain areas and the behavioral performance.

Conclusions: Late monocular blindness involves brain function network dysfunction in many regions, which might indicate impairment of the visual cortex and other vision-related brain regions in the MBs.

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