Flexor Tendon: Development, Healing, Adhesion Formation, and Contributing Growth Factors

Overview

Journal Plast Reconstr Surg

Specialty General Surgery

Date 2019 Oct 1

PMID 31568303

Citations 46

Authors

Ashley L Titan

Deshka S Foster

James Chang

Michael T Longaker

Affiliations

Soon will be listed here.

Abstract

Management of flexor tendon injuries of the hand remains a major clinical problem. Even with intricate repair, adhesion formation remains a common complication. Significant progress has been made to better understand the mechanisms of healing and adhesion formation. However, there has been slow progress in the clinical prevention and reversal of flexor tendon adhesions. The goal of this article is to discuss recent literature relating to tendon development, tendon healing, and adhesion formation to identify areas in need of further research. Additional research is needed to understand and compare the molecular, cellular, and genetic mechanisms involved in flexor tendon morphogenesis, postoperative healing, and mechanical loading. Such knowledge is critical to determine how to improve repair outcomes and identify new therapeutic strategies to promote tissue regeneration and prevent adhesion formation.

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