Matrix-producing Breast Carcinoma: A Rare Subtype of Metaplastic Breast Carcinoma

Overview

Journal Cureus

Specialty Biomedical Engineering

Date 2019 Oct 1

PMID 31565596

Citations 9

Authors

Nektarios Koufopoulos

Stefania Kokkali

Foteini Antoniadou

Dionysios T Dimas

Ioannis L Missitzis

Affiliations

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Abstract

Matrix-producing carcinoma (MPC) is a rare subtype of metaplastic breast carcinoma (MBC) that was first described in 1989 by Wargotz and Norris. It accounts for less than 1% of breast carcinomas and has distinctive clinical, morphological, and immunohistochemical features. Histologically it consists of invasive carcinoma of no special type with transition to cartilaginous or osseous matrix without a spindle cell component. Data on this entity are limited with the literature consisting mostly of case reports and a small number of case series. We report a case of matrix-producing breast carcinoma, with excellent clinical outcome. We also discuss the histogenesis, imaging, histological, and immunohistochemical characteristics, treatment, and focus on the differential diagnosis of this rare tumor.

Citing Articles

The "Forgotten" Subtypes of Breast Carcinoma: A Systematic Review of Selected Histological Variants Not Included or Not Recognized as Distinct Entities in the Current World Health Organization Classification of Breast Tumors.

Koufopoulos N, Boutas I, Pouliakis A, Samaras M, Kotanidis C, Kontogeorgi A Int J Mol Sci. 2024; 25(15).

PMID: 39125951 PMC: 11313581. DOI: 10.3390/ijms25158382.

Metaplastic breast carcinoma with osseous differentiation: A report of a rare case and literature review.

Huang C, Tian H, Xu J, Tong F, Fang D Open Life Sci. 2023; 18(1):20220640.

PMID: 37528884 PMC: 10389674. DOI: 10.1515/biol-2022-0640.

Case Report: Gastric cancer with chondromyxoid matrix similar matrix-producing metaplastic breast carcinoma: report of an undescribed entity.

Wu X, He H, Zhao L, Zeng Z, Yuan J Front Oncol. 2023; 13:1087241.

PMID: 37274268 PMC: 10235811. DOI: 10.3389/fonc.2023.1087241.

Mammary Myofibroblastoma: Report of a Case and Review of the Literature.

Koufopoulos N, Gouloumis A, Dimas D, Kontogeorgi A, Sitara K, Boutas I Cureus. 2023; 14(12):e32371.

PMID: 36632265 PMC: 9827076. DOI: 10.7759/cureus.32371.

Diagnostically Challenging Subtypes of Invasive Lobular Carcinomas: How to Avoid Potential Diagnostic Pitfalls.

Koufopoulos N, Pateras I, Gouloumis A, Ieronimaki A, Zacharatou A, Spathis A Diagnostics (Basel). 2022; 12(11).

PMID: 36359501 PMC: 9689338. DOI: 10.3390/diagnostics12112658.

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