Self-Injurious Behaviour in SCA17: A New Clinical Observation

Overview

Journal Tremor Other Hyperkinet Mov (N Y)

Publisher Ubiquity Press

Date 2019 Oct 1

PMID 31565537

Citations 4

Authors

Roberta Bonomo

Anna Latorre

Kailash P Bhatia

Affiliations

Soon will be listed here.

Abstract

Background: Self-injurious behaviour has historically been associated with borderline personality disorder. Nevertheless, over recent years, it has been reported in numerous neurological syndromes, especially hyperkinesias.

Case Report: Two cases of SCA17 manifested self-injurious behaviour, namely repetitive scratching of the skin resulting in severe excoriations. In one of them, the abnormal behaviour was associated with the inability to resist the impulse to commit the act along with relief following the damage.

Discussion: This is the first report describing self-injurious behaviour in SCA17, but the mechanisms underlying it are still not clear. Further studies are needed to clarify the pathophysiology of such manifestation in hyperkinetic syndromes.

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Atypical parkinsonism and self-mutilation: A new lens on the old concept.

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Severe Scratching in Spinocerebellar Ataxia 17: Another Case.

Pauly M, Munchau A, Bruggemann N Tremor Other Hyperkinet Mov (N Y). 2020; 10:15.

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References

Gardner D, Cowdry R . Suicidal and parasuicidal behavior in borderline personality disorder. Psychiatr Clin North Am. 1985; 8(2):389-403. View

Folstein M, Folstein S, McHugh P . "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res. 1975; 12(3):189-98. DOI: 10.1016/0022-3956(75)90026-6. View

Jathar P, Panse A, Jathar M, Gawali P . Lesch-Nyhan Syndrome: Disorder of Self-mutilating Behavior. Int J Clin Pediatr Dent. 2016; 9(2):139-42. PMC: 4921883. DOI: 10.5005/jp-journals-10005-1350. View

Pattison E, Kahan J . The deliberate self-harm syndrome. Am J Psychiatry. 1983; 140(7):867-72. DOI: 10.1176/ajp.140.7.867. View

Danek A, Walker R . Neuroacanthocytosis. Curr Opin Neurol. 2005; 18(4):386-92. DOI: 10.1097/01.wco.0000173464.01888.e9. View

Schmitz-Hubsch T, Tezenas Du Montcel S, Baliko L, Berciano J, Boesch S, Depondt C . Scale for the assessment and rating of ataxia: development of a new clinical scale. Neurology. 2006; 66(11):1717-20. DOI: 10.1212/01.wnl.0000219042.60538.92. View

Amato D, Canneva F, Nguyen H, Bauer P, Riess O, von Horsten S . Capturing schizophrenia-like prodromal symptoms in a spinocerebellar ataxia-17 transgenic rat. J Psychopharmacol. 2016; 31(4):461-473. DOI: 10.1177/0269881116675510. View

Mizuno T, YUGARI Y . Letter: Self mutilation in Lesch-Nyhan syndrome. Lancet. 1974; 1(7860):761. DOI: 10.1016/s0140-6736(74)92990-0. View

Maltecca F, Filla A, Castaldo I, Coppola G, Fragassi N, Carella M . Intergenerational instability and marked anticipation in SCA-17. Neurology. 2003; 61(10):1441-3. DOI: 10.1212/01.wnl.0000094123.09098.a0. View

10.

Walker R, Liu Q, Ichiba M, Muroya S, Nakamura M, Sano A . Self-mutilation in chorea-acanthocytosis: Manifestation of movement disorder or psychopathology?. Mov Disord. 2006; 21(12):2268-9. DOI: 10.1002/mds.21156. View

11.

Latorre A, Salgado P, Salari M, Jesuthasan A, Bhatia K . Combined Dystonia With Self-Mutilation in 6-Pyruvoyl-Tetrahydropterin Synthase (PTPS) Deficiency: A Case Report. Mov Disord Clin Pract. 2019; 6(1):81-82. PMC: 6335374. DOI: 10.1002/mdc3.12698. View

12.

Nanda A, Jackson S, Schwankhaus J, Metzer W . Case of spinocerebellar ataxia type 17 (SCA17) associated with only 41 repeats of the TATA-binding protein (TBP) gene. Mov Disord. 2006; 22(3):436. DOI: 10.1002/mds.21275. View

13.

Singh N, Pulman R . Self-injury in the de Lange syndrome. J Ment Defic Res. 1979; 23(2):79-84. DOI: 10.1111/j.1365-2788.1979.tb00044.x. View

14.

Palermo S, Morese R, Zibetti M, Dematteis F, Sirgiovanni S, Stanziano M . Impulse control disorder and response-inhibition alterations in Parkinson's disease. A rare case of totally absent functionality of the medial-prefrontal cortex and review of literature. J Adv Res. 2017; 8(6):713-716. PMC: 5633757. DOI: 10.1016/j.jare.2017.09.004. View

15.

Koide R, Kobayashi S, Shimohata T, Ikeuchi T, Maruyama M, Saito M . A neurological disease caused by an expanded CAG trinucleotide repeat in the TATA-binding protein gene: a new polyglutamine disease?. Hum Mol Genet. 1999; 8(11):2047-53. DOI: 10.1093/hmg/8.11.2047. View

16.

Bryson Y, Sakati N, Nyhan W, Fish C . Self-mutilative behavior in the Cornelia de Lange syndrome. Am J Ment Defic. 1971; 76(3):319-24. View

17.

Goldstein M, ANDERSON L, Reuben R, DANCIS J . Self-mutilation in Lesch-Nyhan disease is caused by dopaminergic denervation. Lancet. 1985; 1(8424):338-9. DOI: 10.1016/s0140-6736(85)91107-9. View

18.

Sandyk R . Naloxone abolishes self-injuring in a mentally retarded child. Ann Neurol. 1985; 17(5):520. DOI: 10.1002/ana.410170521. View

19.

Gillman M, Sandyk R . Opiatergic and dopaminergic function and Lesch-Nyhan syndrome. Am J Psychiatry. 1985; 142(10):1226. DOI: 10.1176/ajp.142.10.1226a. View

20.

Coid J, Allolio B, Rees L . Raised plasma metenkephalin in patients who habitually mutilate themselves. Lancet. 1983; 2(8349):545-6. DOI: 10.1016/s0140-6736(83)90572-x. View