HOXC13-AS-miR-122-5p-SATB1-C-Myc Feedback Loop Promotes Migration, Invasion and EMT Process in Glioma

Overview

Journal Onco Targets Ther

Publisher Dove Medical Press

Specialty Oncology

Date 2019 Oct 1

PMID 31564901

Citations 12

Authors

Ning Liu

Ziyu Wang

DaChao Liu

Peng Xie

Affiliations

Soon will be listed here.

Abstract

Purpose: Differentially expressed long non-coding ribonucleic acids (lncRNAs) have been reported as a key factor of glioma carcinogenesis, but the underlying mechanism involved is still unknown.

Materials And Methods: In the present study, lncRNA HOXC13 antisense RNA (HOXC13-AS) was identified as a potential oncogene in glioma, and Western blotting, wound healing and Transwell assays were carried out to explore the effects of HOXC13-AS on the epithelial-mesenchymal transition (EMT) process as well as the migration and invasion of glioma cells.

Results: A further mechanistic study showed that HOXC13-AS sponged miR-122-5p to indirectly regulate SATB1 expression and affect the EMT process via the Wnt/β-catenin pathway. Meanwhile, the promoter activity was significantly increased via c-Myc, a key factor of the Wnt/β-catenin pathway, thus forming a positive HOXC13-AS-miR-122-5p-SATB1-c-Myc feedback loop to drive the malignant behavior in glioma.

Discussion: This study evidences the constitutive HOXC13-AS-miR-122-5p-SATB1-c-Myc feedback loop and provides a potential therapeutic target for glioma treatment.

Citing Articles

The diagnostic and prognostic significance of HOXC13-AS and its molecular regulatory mechanism in human cancer.

Gu X, Hu X, Zhang S, Zhang X, Wang Y, Li L Front Mol Biosci. 2025; 12:1540048.

PMID: 39981436 PMC: 11839424. DOI: 10.3389/fmolb.2025.1540048.

Regulation of EMT Markers, Extracellular Matrix, and Associated Signalling Pathways by Long Non-Coding RNAs in Glioblastoma Mesenchymal Transition: A Scoping Review.

Leung D, Phon B, Sivalingam M, Radhakrishnan A, Kamarudin M Biology (Basel). 2023; 12(6).

PMID: 37372103 PMC: 10294841. DOI: 10.3390/biology12060818.

Human skin specific long noncoding RNA HOXC13-AS regulates epidermal differentiation by interfering with Golgi-ER retrograde transport.

Zhang L, Piipponen M, Liu Z, Li D, Bian X, Niu G Cell Death Differ. 2023; 30(5):1334-1348.

PMID: 36869179 PMC: 10154349. DOI: 10.1038/s41418-023-01142-z.

The "Superoncogene" Myc at the Crossroad between Metabolism and Gene Expression in Glioblastoma Multiforme.

Cencioni C, Scagnoli F, Spallotta F, Nasi S, Illi B Int J Mol Sci. 2023; 24(4).

PMID: 36835628 PMC: 9966483. DOI: 10.3390/ijms24044217.

Long non-coding RNA UCA1 promotes retinoblastoma progression by modulating the miR-124/c-myc axis.

Wang L, Wu M, Zhou X Am J Transl Res. 2022; 14(3):1592-1605.

PMID: 35422898 PMC: 8991135.

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