Network Pharmacology Study on the Active Components of and the Mechanism of Their Effect Against Cerebral Ischemia

Overview

Journal Drug Des Devel Ther

Specialty Pharmacology

Date 2019 Oct 1

PMID 31564827

Citations 11

Authors

Bingxuan Niu

Hui Zhang

Chunyan Li

Fulin Yan

Yu Song

Guangfan Hai

Yunjuan Jiao

Yansheng Feng

Affiliations

Soon will be listed here.

Abstract

Objective: The aim of this study was to identify the active anti-ischemic components of () using a network pharmacology approach to construct an effective component anti-cerebral ischemic target network and systematically analyze this medicinal material.

Methods: Pharmacological studies have shown that has an obvious effect against cerebral ischemia. To identify the potential targets, 14 components of were docked to each structural element of the targets in the DRAR-CPI database by reverse docking technology. We then compared the identified potential targets with FDA-approved targets for stroke/cerebral infarction treatment in the DrugBank database and identified the active components of and their potential targets for stroke/cerebral infarction treatment. The active component-target networks were constructed using Cytoscape 3.5.1 software. The target protein-protein interactions were analyzed using the STRING database. KEGG pathway analysis and gene ontology (GO) enrichment analysis were performed through the Database for Annotation, Visualization and Integrated Discovery (DAVID).

Results: There were 14 active components identified from and 21 potential targets identified for cerebral ischemia treatment, including carbonic anhydrase 2, ribosyldihydronicotinamide dehydrogenase, cholinesterase, and glutathione S-transferase P. The main involved pathways include metabolic pathways, complement and coagulation cascades and steroid hormone biosynthesis.

Conclusion: Through a network pharmacology approach, we predicted the active components of and their potential targets for cerebral ischemia treatment. Our results provide new perspectives and clues for further studies on the anti-cerebral ischemia mechanism of .

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