Alzheimer Disease: An Update on Pathobiology and Treatment Strategies

Overview

Journal Cell

Publisher Cell Press

Specialty Cell Biology

Date 2019 Oct 1

PMID 31564456

Citations 1121

Authors

Justin M Long

David M Holtzman

Affiliations

Soon will be listed here.

Abstract

Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The presence of extracellular β-amyloid deposition as neuritic plaques and intracellular accumulation of hyperphosphorylated tau as neurofibrillary tangles remains the primary neuropathologic criteria for AD diagnosis. However, a number of recent fundamental discoveries highlight important pathological roles for other critical cellular and molecular processes. Despite this, no disease-modifying treatment currently exists, and numerous phase 3 clinical trials have failed to demonstrate benefits. Here, we review recent advances in our understanding of AD pathobiology and discuss current treatment strategies, highlighting recent clinical trials and opportunities for developing future disease-modifying therapies.

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