Smoking History, Intensity, and Duration and Risk of Prostate Cancer Recurrence Among Men with Prostate Cancer Who Received Definitive Treatment

Overview

Journal Ann Epidemiol

Publisher Elsevier

Specialty Public Health

Date 2019 Sep 30

PMID 31563295

Citations 2

Authors

Saira Khan

Shivani Thakkar

Bettina Drake

Affiliations

Soon will be listed here.

Abstract

Purpose: To examine the association of smoking history and multiple measures of smoking intensity and duration with risk of biochemical recurrence in men treated for prostate cancer.

Methods: We conducted a prospective cohort study of 1641 men (773 ever-smokers) treated with radical prostatectomy or radiation between 2003 and 2010. The association between ever-smoking and risk of biochemical recurrence was examined using Cox Proportional Hazards models with adjustment for confounders. Among ever-smokers, we further assessed the association between multiple measures of smoking duration and intensity and risk of biochemical recurrence.

Results: In the full cohort, we observed no association between ever-smoking and risk of biochemical recurrence. However, among ever-smokers, a smoking duration of greater than or equal to 10 years was significantly associated with biochemical recurrence (hazard ratio: 2.32, 95% confidence interval: 1.01, 5.33). Our results also suggested that greater than or equal to 10 pack-years of smoking may be associated with an increased risk of biochemical recurrence (hazard ratio: 1.75, 95% confidence interval: 0.97, 3.15). No association was observed between packs smoked per day or years since smoking cessation (among former smokers) and risk of biochemical recurrence.

Conclusion: Smoking duration is a significant predicator of biochemical recurrence among men with prostate cancer who are current or former smokers.

Citing Articles

Cigarette smoking and prostate cancer aggressiveness among African and European American men.

Ellis E, Fairman B, Stahr S, Bensen J, Mohler J, Song L Cancer Causes Control. 2024; 35(9):1259-1269.

PMID: 38758522 PMC: 11377453. DOI: 10.1007/s10552-024-01883-3.

Underlying Features of Prostate Cancer-Statistics, Risk Factors, and Emerging Methods for Its Diagnosis.

Berenguer C, Pereira F, Camara J, Pereira J Curr Oncol. 2023; 30(2):2300-2321.

PMID: 36826139 PMC: 9955741. DOI: 10.3390/curroncol30020178.

References

Pantarotto J, Malone S, Dahrouge S, Gallant V, Eapen L . Smoking is associated with worse outcomes in patients with prostate cancer treated by radical radiotherapy. BJU Int. 2006; 99(3):564-9. DOI: 10.1111/j.1464-410X.2006.06656.x. View

Cookson M, Aus G, Burnett A, Canby-Hagino E, DAmico A, Dmochowski R . Variation in the definition of biochemical recurrence in patients treated for localized prostate cancer: the American Urological Association Prostate Guidelines for Localized Prostate Cancer Update Panel report and recommendations for a standard in.... J Urol. 2007; 177(2):540-5. DOI: 10.1016/j.juro.2006.10.097. View

Vanden Driessche K, Patel M, Mbonze N, Tabala M, Yotebieng M, Behets F . Effect of smoking history on outcome of patients diagnosed with TB and HIV. Eur Respir J. 2014; 45(3):839-42. PMC: 7315258. DOI: 10.1183/09031936.00160714. View

Kenfield S, Stampfer M, Chan J, Giovannucci E . Smoking and prostate cancer survival and recurrence. JAMA. 2011; 305(24):2548-55. PMC: 3562349. DOI: 10.1001/jama.2011.879. View

White W, Cain L, Benjamin E, DeFilippis A, Blaha M, Wang W . High-Intensity Cigarette Smoking Is Associated With Incident Diabetes Mellitus In Black Adults: The Jackson Heart Study. J Am Heart Assoc. 2018; 7(2). PMC: 5850161. DOI: 10.1161/JAHA.117.007413. View

Steinberger E, Kollmeier M, McBride S, Novak C, Pei X, Zelefsky M . Cigarette smoking during external beam radiation therapy for prostate cancer is associated with an increased risk of prostate cancer-specific mortality and treatment-related toxicity. BJU Int. 2014; 116(4):596-603. DOI: 10.1111/bju.12969. View

Moreira D, Antonelli J, Presti Jr J, Aronson W, Terris M, Kane C . Association of cigarette smoking with interval to biochemical recurrence after radical prostatectomy: results from the SEARCH database. Urology. 2010; 76(5):1218-23. PMC: 3177236. DOI: 10.1016/j.urology.2010.01.066. View

Murata Y, Tatsugami K, Yoshikawa M, Hamaguchi M, Yamada S, Hayakawa Y . Predictive factors of biochemical recurrence after radical prostatectomy for high-risk prostate cancer. Int J Urol. 2018; 25(3):284-289. DOI: 10.1111/iju.13514. View

Skolarus T, Wolf A, Erb N, Brooks D, Rivers B, Underwood 3rd W . American Cancer Society prostate cancer survivorship care guidelines. CA Cancer J Clin. 2014; 64(4):225-49. DOI: 10.3322/caac.21234. View

10.

Feng X, Qian Z, Zhang B, Guo E, Wang L, Liu P . Number of Cigarettes Smoked Per Day, Smoking Index, and Intracranial Aneurysm Rupture: A Case-Control Study. Front Neurol. 2018; 9:380. PMC: 5990590. DOI: 10.3389/fneur.2018.00380. View

11.

Chun F, Karakiewicz P, Briganti A, Gallina A, Kattan M, Montorsi F . Prostate cancer nomograms: an update. Eur Urol. 2006; 50(5):914-26. DOI: 10.1016/j.eururo.2006.07.042. View

12.

Siegel R, Miller K, Jemal A . Cancer statistics, 2018. CA Cancer J Clin. 2018; 68(1):7-30. DOI: 10.3322/caac.21442. View

13.

Shariat S, Karakiewicz P, Roehrborn C, Kattan M . An updated catalog of prostate cancer predictive tools. Cancer. 2008; 113(11):3075-99. DOI: 10.1002/cncr.23908. View

14.

Roach 3rd M, Hanks G, Thames Jr H, Schellhammer P, Shipley W, Sokol G . Defining biochemical failure following radiotherapy with or without hormonal therapy in men with clinically localized prostate cancer: recommendations of the RTOG-ASTRO Phoenix Consensus Conference. Int J Radiat Oncol Biol Phys. 2006; 65(4):965-74. DOI: 10.1016/j.ijrobp.2006.04.029. View

15.

Gillison M, Zhang Q, Jordan R, Xiao W, Westra W, Trotti A . Tobacco smoking and increased risk of death and progression for patients with p16-positive and p16-negative oropharyngeal cancer. J Clin Oncol. 2012; 30(17):2102-11. PMC: 3397696. DOI: 10.1200/JCO.2011.38.4099. View

16.

Khan S, Hicks V, Colditz G, Kibel A, Drake B . The association of weight change in young adulthood and smoking status with risk of prostate cancer recurrence. Int J Cancer. 2017; 142(10):2011-2018. PMC: 5867243. DOI: 10.1002/ijc.31229. View

17.

Kolodziej M . Management of biochemically recurrent prostate cancer following local therapy. Am J Manag Care. 2015; 20(12 Suppl):S273-81. View

18.

De Nunzio C, Andriole G, Thompson Jr I, Freedland S . Smoking and Prostate Cancer: A Systematic Review. Eur Urol Focus. 2017; 1(1):28-38. DOI: 10.1016/j.euf.2014.10.002. View

19.

Stephenson A, Scardino P, Eastham J, Bianco Jr F, Dotan Z, DiBlasio C . Postoperative nomogram predicting the 10-year probability of prostate cancer recurrence after radical prostatectomy. J Clin Oncol. 2005; 23(28):7005-12. PMC: 2231088. DOI: 10.1200/JCO.2005.01.867. View

20.

Merrick G, Butler W, Wallner K, Galbreath R, Lief J, Adamovich E . Effect of cigarette smoking on biochemical outcome after permanent prostate brachytherapy. Int J Radiat Oncol Biol Phys. 2004; 58(4):1056-62. DOI: 10.1016/j.ijrobp.2003.08.021. View