Determinants of Maximum Cup Depth in Non-glaucoma and Primary Open-angle Glaucoma Subjects: a Population-based Study

Overview

Journal Eye (Lond)

Specialty Ophthalmology

Date 2019 Sep 29

PMID 31562382

Citations 2

Authors

Qing Zhang

Ye Zhang

Chen Xin

Yingyan Mao

Kai Cao

Catherine Jan

Chunyu Guo

Ningli Wang

Ravi Thomas

Affiliations

Soon will be listed here.

Abstract

Background/objectives: To study the associations of intraocular pressure (IOP) and retinal vessel diameters: central retinal arteriolar equivalent (CRAE) and central retinal venular equivalent (CRVE) with the maximum cup depth (MCD) in subjects with and without POAG.

Subjects/methods: Eligible subjects from the Handan Eye Study. All participants underwent physical and comprehensive eye examinations. Univariable and multivariable linear regression models assessed the association between MCD and other parameters.

Results: Four thousand one hundred and ninety-four eligible nonglaucoma and 40 POAG subjects were analyzed. On univariable analysis, deeper MCD was significantly associated with younger age, male gender, lower systolic blood pressure (BP), higher IOP, higher estimated cerebro-spinal fluid pressure (ECSFP), lower estimated trans-laminal cribrosa pressure difference (ETLCPD), longer axial length, narrower CRAE, narrower CRVE, larger disc area (DA) and a lower prevalence of hypertension and diabetes. On multivariable analysis, significant independent determinants of MCD were larger DA (P < 0.001; beta: 0.042; B: 0.20; 95% CI: 0.19, 0.22), younger age (P < 0.001; beta: -0.09; B: -0.002; 95% CI: -0.003, -0.001), higher IOP (P < 0.01; beta: 0.040; B: 0.003; 95% CI: 0.001, 0.005), and narrower CRAE (P < 0.001; beta: -0.06; B: -0.001; 95% CI: -0.001, -0.0003). On adding ECSFP and ETLCPD to the model, MCD was associated with IOP but not with estimated CSFP and TLCPD. A 1 μm decrease in CRAE or 1 mmHg increase of IOP was associated with a 1 μm increase of MCD (P < 0.001) and 3 μm increase of MCD respectively (P = 0.009).

Conclusions: Narrow CRVE and higher IOP are associated with an increase in MCD.

Citing Articles

The association between asymmetric stress distribution on the lamina cribrosa and glaucoma progression.

Kang E, Park J, Yoo C, Kim Y Graefes Arch Clin Exp Ophthalmol. 2024; .

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Three-Decade Evaluation of Cerebrospinal Fluid Pressure in Open-Angle Glaucoma at a Tertiary Care Center.

Knier C, Fleischman D, Hodge D, Berdahl J, Fautsch M J Ophthalmol. 2021; 2020:7487329.

PMID: 34527373 PMC: 8437650. DOI: 10.1155/2020/7487329.

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