Abnormalities in the Expression of the Leucocyte-common Antigen in Chronic Lymphocytic Leukaemia

Overview

Journal Clin Exp Immunol

Publisher Oxford University Press

Specialty Allergy & Immunology

Date 1985 Jan 1

PMID 3156016

Citations 2

Authors

S K Smith

V A Brown

A E Dewar

G Stockdill

B Cohen

A H Maddy

Affiliations

Soon will be listed here.

Abstract

The surface glycoproteins of lymphocytes isolated from patients suffering from B cell chronic lymphocytic leukaemia (B-CLL) have been studied by radioactive labelling with impermeable probes and with MoAb. Several features not found in normal B cells have been observed. The abnormalities found in the expression of polypeptides of the leucocyte common (L-C) antigen, identified by appropriate MoAb, have been examined in detail. It has been shown by both biochemical analysis and MoAb binding that this group of polypeptides can, within a panel of B-CLL patients, range from a typical B cell pattern to the pattern resembling that normally found in T cells. The T lymphocyte profile is correlated with a poor prognosis (MVA C rating) and in the one patient where a change in the glycoprotein profile towards that of the T cell was observed, the change coincided with a clinical deterioration. The biological significance of the molecular diversity is discussed.

Citing Articles

Surface glycoproteins as markers of the cellular status of B chronic lymphocytic leukaemia lymphocytes.

Brown V, Smith S, Dewar A, Stockdill G, Maddy A Clin Exp Immunol. 1985; 62(1):95-103.

PMID: 3877584 PMC: 1577409.

The role of cell maturation in the generation of phenotypic heterogeneity in B-cell chronic lymphocytic leukaemia.

Maddy A, Sanderson A, Mackie M, Smith S Immunology. 1989; 68(3):346-52.

PMID: 2531721 PMC: 1385446.

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