Dorsal Tongue Porphyrin Autofluorescence and Candida saprophytism: A prospective Observational Study

Overview

Journal PLoS One

Specialties General Medicine
Science

Date 2019 Sep 27

PMID 31557235

Citations 5

Authors

Massimo Petruzzi

Fedora Della Vella

Andrea Cassandro

Adriana Mosca

Mariasevera Di Comite

Maria Contaldo

Felice Roberto Grassi

Dorina Lauritano

Affiliations

Soon will be listed here.

Abstract

Aim: To investigate the correlation between the dorsal tongue porphyrin autofluorescence, revealed using VELscope, and Candida saprophytism.

Material And Methods: Consecutive patients underwent an autofluorescence examination by the VELscope device to establish the presence or absence of porphyrin fluorescence. A tongue swab was collected for the Candida cultural test. Sensitivity, specificity, accuracy, negative predictive value and positive predictive value were calculated considering the oral swab as the gold standard. The degree of agreement between the two tests was calculated using Cohen's K coefficient.

Results: One hundred twenty-six patients were enrolled. Porphyrin fluorescence method showed a sensitivity of 78%, specificity of 76% and an accuracy of 78%. Negative predictive value and positive predictive value were respectively 90% and 59%. The strength of agreement between the two methods resulted to be moderate (k = 0.551).

Conclusions: Off-label use of tongue autofluorescence examination to detect the presence of Candida species is characterized by a loss of porphyrin fluorescence. The high negative predictive value of porphyrin fluorescence loss suggests its use in preliminary selection of Candida carriers, in order to plan preventive and therapeutic strategies.

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