Preoperative D-dimer Level is an Independent Prognostic Factor for Non-small Cell Lung Cancer After Surgical Resection: a Systematic Review and Meta-analysis

Overview

Journal Ann Transl Med

Publisher AME Publishing Company

Date 2019 Sep 27

PMID 31555680

Citations 10

Authors

Han-Yu Deng

Xi Zheng

Rui Jiang

Rui-Lan Wang

Jie Zhou

Xiao-Ming Qiu

Affiliations

Soon will be listed here.

Abstract

Background: Whether high preoperative D-dimer level has any impact on long-term survival of patients with surgically treated non-small cell lung cancer (NSCLC) remains unclear. Therefore, we conducted the first meta-analysis focusing specifically on prognostic value of high preoperative D-dimer level in NSCLC patients after surgical resection comprehensively.

Methods: We conducted a systematic search for relevant studies in PubMed, Embase, and Web of Science on January 28, 2019. Data for analysis consisted of hazard ratio (HR) with 95% confidence interval (CI) of overall survival (OS) and disease-free survival (DFS) from multivariate analysis and were analyzed by using the STATA 12.0 package.

Results: Finally, we included a total of 6 cohort studies consisting of 1,817 patients with surgically treated NSCLC for analysis. Our meta-analysis found that NSCLC patients with high preoperative D-dimer level had a significantly worse OS (random effects: HR =2.04; 95% CI: 1.30-3.20; P=0.002; I=67.4%) and DFS (fixed effects: HR =1.98; 95% CI: 1.41-2.78; P<0.001; I=0.0%) than these with normal preoperative D-dimer level after surgery. However, potential heterogeneity and publication bias was observed during analysis.

Conclusions: High pretreatment level of D-dimer remains to be an independent predictor of poor prognosis in NSCLC patients after surgery. Further well-conducted studies with appropriate adjustments are needed to confirm and update our conclusions.

Citing Articles

D-Dimers Variability in the Perioperative Period of Breast Cancer Surgery Helps to Predict Cancer Relapse: A Single-Centre Prospective Study.

Dybowska M, Dybowski D, Szturmowicz M, Jozwik A, Lewandowska K, Sobiecka M Cancer Control. 2023; 30:10732748231204713.

PMID: 37791647 PMC: 10552458. DOI: 10.1177/10732748231204713.

Paired Analysis of D-Dimer and Its Correlated Hemostatic Parameters in 30 Dogs with Neoplasms after Tumorectomy.

Ke C, Liu C, Wang S, Lin C Animals (Basel). 2023; 13(6).

PMID: 36978511 PMC: 10044208. DOI: 10.3390/ani13060969.

Prognostic value of plasma D-dimer levels in advanced non-small cell lung cancer patients treated with immune checkpoint inhibitors: a retrospective study.

Li X, Lu D, Zhang Z, Zhang Y, Wang J, Hu Y J Thorac Dis. 2022; 14(10):4125-4135.

PMID: 36389301 PMC: 9641356. DOI: 10.21037/jtd-22-1363.

A Nomogram Combining Neutrophil-to-Lymphocyte Ratio and D-Dimer Predicts Chemosensitivity of Oxaliplatin-Based First-Line Chemotherapy in Patients with Unresectable Advanced Gastric Cancer.

Shen H, Wu S, Su R, Chen Y, He Y Technol Cancer Res Treat. 2022; 21:15330338221112741.

PMID: 35880288 PMC: 9340318. DOI: 10.1177/15330338221112741.

Incidence of venous thromboembolism and hemorrhage in Chinese patients after pulmonary lobectomy: mechanical prophylaxis or mechanical prophylaxis combined with pharmacological prophylaxis: a randomized controlled trial.

Hong Y, Zhang Y, Xiang Y, Ye Z, Lu X Ann Transl Med. 2021; 9(18):1478.

PMID: 34734030 PMC: 8506730. DOI: 10.21037/atm-21-4231.

References

Mavromatis B, Kessler C . D-dimer testing: the role of the clinical laboratory in the diagnosis of pulmonary embolism. J Clin Pathol. 2001; 54(9):664-8. PMC: 1731521. DOI: 10.1136/jcp.54.9.664. View

Antoniou D, Pavlakou G, Stathopoulos G, Karydis I, Chondrou E, Papageorgiou C . Predictive value of D-dimer plasma levels in response and progressive disease in patients with lung cancer. Lung Cancer. 2006; 53(2):205-10. DOI: 10.1016/j.lungcan.2006.03.015. View

Molina J, Yang P, Cassivi S, Schild S, Adjei A . Non-small cell lung cancer: epidemiology, risk factors, treatment, and survivorship. Mayo Clin Proc. 2008; 83(5):584-94. PMC: 2718421. DOI: 10.4065/83.5.584. View

Falanga A, Panova-Noeva M, Russo L . Procoagulant mechanisms in tumour cells. Best Pract Res Clin Haematol. 2009; 22(1):49-60. DOI: 10.1016/j.beha.2008.12.009. View

Kvolik S, Jukic M, Matijevic M, Marjanovic K, Glavas-Obrovac L . An overview of coagulation disorders in cancer patients. Surg Oncol. 2009; 19(1):e33-46. DOI: 10.1016/j.suronc.2009.03.008. View

Moher D, Liberati A, Tetzlaff J, Altman D . Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. PLoS Med. 2009; 6(7):e1000097. PMC: 2707599. DOI: 10.1371/journal.pmed.1000097. View

Goldstraw P, Ball D, Jett J, Le Chevalier T, Lim E, Nicholson A . Non-small-cell lung cancer. Lancet. 2011; 378(9804):1727-40. DOI: 10.1016/S0140-6736(10)62101-0. View

Falanga A, Vignoli A, Diani E, Marchetti M . Comparative assessment of low-molecular-weight heparins in cancer from the perspective of patient outcomes and survival. Patient Relat Outcome Meas. 2012; 2:175-88. PMC: 3417933. DOI: 10.2147/PROM.S10099. View

Gadgeel S, Ramalingam S, Kalemkerian G . Treatment of lung cancer. Radiol Clin North Am. 2012; 50(5):961-74. DOI: 10.1016/j.rcl.2012.06.003. View

10.

Falanga A, Marchetti M, Vignoli A . Coagulation and cancer: biological and clinical aspects. J Thromb Haemost. 2013; 11(2):223-33. DOI: 10.1111/jth.12075. View

11.

Zhang P, Sun J, Wang X, Liu X, Li K . Preoperative plasma D-dimer levels predict survival in patients with operable non-small cell lung cancer independently of venous thromboembolism. Eur J Surg Oncol. 2013; 39(9):951-6. DOI: 10.1016/j.ejso.2013.06.008. View

12.

Zhou Y, Yang Z, Feng J, Shan Y, Wang W, Mei Y . High plasma D-dimer level is associated with decreased survival in patients with lung cancer: a meta-analysis. Tumour Biol. 2013; 34(6):3701-4. DOI: 10.1007/s13277-013-0953-2. View

13.

Ma X, Li Y, Zhang J, Huang J, Liu L . Prognostic role of D-dimer in patients with lung cancer: a meta-analysis. Tumour Biol. 2013; 35(3):2103-9. DOI: 10.1007/s13277-013-1279-9. View

14.

Fukumoto K, Taniguchi T, Usami N, Kawaguchi K, Fukui T, Ishiguro F . Preoperative plasma D-dimer level is an independent prognostic factor in patients with completely resected non-small cell lung cancer. Surg Today. 2014; 45(1):63-7. DOI: 10.1007/s00595-014-0894-4. View

15.

Jiang H, Li J, Shi S, Chen P, Ge L, Jiang Q . Value of fibrinogen and D-dimer in predicting recurrence and metastasis after radical surgery for non-small cell lung cancer. Med Oncol. 2014; 31(7):22. DOI: 10.1007/s12032-014-0022-8. View

16.

Ge L, Li J, Bao Q, Chen P, Jiang Q, Zhu L . Prognostic and predictive value of plasma D-dimer in advanced non-small cell lung cancer patients undergoing first-line chemotherapy. Clin Transl Oncol. 2014; 17(1):57-64. DOI: 10.1007/s12094-014-1198-2. View

17.

Zhang X, Liu Z, Zhang W, Xu Q . A retrospective analysis of plasma D-dimer dynamic variation in terminal stage cancer patients: implications for disease progression. Int J Clin Exp Med. 2014; 7(8):2395-401. PMC: 4161605. View

18.

Oser M, Niederst M, Sequist L, Engelman J . Transformation from non-small-cell lung cancer to small-cell lung cancer: molecular drivers and cells of origin. Lancet Oncol. 2015; 16(4):e165-72. PMC: 4470698. DOI: 10.1016/S1470-2045(14)71180-5. View

19.

Wang Y, Wang Z . Predictive value of plasma D-dimer levels in patients with advanced non-small-cell lung cancer. Onco Targets Ther. 2015; 8:805-8. PMC: 4403698. DOI: 10.2147/OTT.S78154. View

20.

Chen F, Wang M, Li J, Yan C, Han X, Wu Z . Plasma D-dimer value as a predictor of malignant lymph node involvement in operable non-small cell lung cancer. Tumour Biol. 2015; 36(12):9201-7. DOI: 10.1007/s13277-015-3526-8. View