Platelets and Complement Cross-Talk in Early Atherogenesis

Overview

Journal Front Cardiovasc Med

Specialty Cardiology & Vascular Diseases

Date 2019 Sep 27

PMID 31555668

Citations 21

Authors

Hugh Kim

Edward M Conway

Affiliations

Soon will be listed here.

Abstract

Atherosclerosis remains a ubiquitous and serious threat to human health. The initial formation of the atherosclerotic lesion (atheroma) is driven by pro-inflammatory signaling involving monocytes and vascular endothelial cells; later stages of the disease involve rupture of well-established atherosclerotic plaques, thrombosis, and blood vessel occlusion. While the central role of platelets in thrombosis is undisputed, platelets exhibit pro-inflammatory activities, and contribute to early-stage atheroma formation. Platelets also engage components of the complement system, an essential element of innate immunity that contributes to vascular inflammation. Here we provide an overview of the complex interplay between platelets and the complement system, with a focus on how the crosstalk between them may impact on the initiation of atheroma formation.

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