Artificial Gramicidins

Overview

Journal Front Chem

Specialty Chemistry

Date 2019 Sep 26

PMID 31552227

Citations 4

Authors

Zhanhu Sun

Mihail Barboiu

Affiliations

Soon will be listed here.

Abstract

Gramicidin A, gA is a natural protein channel with a well-established, simple structure, and function: cations and water are transported together along the channel. Importantly, the dipolar orientation of water molecules within the pore can influence the ionic translocation. The need for simple artificial systems biomimicking the gA functions has been desired and they were until last decade unknown. Several interesting papers highlighted in this minireview have been published and supramolecular systems described here can be considered as primitive gA mimics. The dynamics of ions/water and protons confined within gA channels is difficult to structurally analyze and simpler artificial systems designed at the atomic level would have a crucial relevance for understanding such translocation scenarios at the molecular level. The directional ordering of confined water-wires or ions, as observed inside primitive gA channels is reminiscent with specific interactions between water and the natural gA. This dipolar orientation may induce specific dielectric properties which most probably influence the biological recognition at bio-interfaces or translocation of charge species along artificial channel pathways.

Citing Articles

Changes in Ion Transport across Biological Membranes Exposed to Particulate Matter.

Hoser J, Dabrowska A, Zajac M, Bednarczyk P Membranes (Basel). 2023; 13(9).

PMID: 37755185 PMC: 10535541. DOI: 10.3390/membranes13090763.

Characterization and Differential Cytotoxicity of Gramicidin Nanoparticles Combined with Cationic Polymer or Lipid Bilayer.

Perez-Betancourt Y, Zaia R, Evangelista M, Ribeiro R, Roncoleta B, Mathiazzi B Pharmaceutics. 2022; 14(10).

PMID: 36297488 PMC: 9610547. DOI: 10.3390/pharmaceutics14102053.

Biomimetic Artificial Proton Channels.

Andrei I, Barboiu M Biomolecules. 2022; 12(10).

PMID: 36291682 PMC: 9599858. DOI: 10.3390/biom12101473.

Beneficial Impacts of Incorporating the Non-Natural Amino Acid Azulenyl-Alanine into the Trp-Rich Antimicrobial Peptide buCATHL4B.

DSouza A, Necelis M, Kulesha A, Caputo G, Makhlynets O Biomolecules. 2021; 11(3).

PMID: 33809374 PMC: 8001250. DOI: 10.3390/biom11030421.

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