Disseminated Thymic B-cell Lymphoma in a Holstein Heifer

Overview

Journal J Vet Diagn Invest

Specialty Veterinary Medicine

Date 2019 Sep 26

PMID 31551023

Citations 4

Authors

Wan N A D Hishamnuri

Shotaro Nakagun

Masaki Maezawa

Kana Sakaguchi

Nao Akiyama

Ken-Ichi Watanabe

Noriyuki Horiuchi

Yoshiyasu Kobayashi

Hisashi Inokuma

Affiliations

Soon will be listed here.

Abstract

A 19-mo-old Holstein heifer was inactive and dyspneic. Physical examination revealed wheezing, exophthalmos, a cervical mass, and lymphadenopathy. Cytology of the cervical mass and lymph nodes showed predominantly large atypical lymphocytes. Lactate dehydrogenase and thymidine kinase activities were elevated. Although nested PCR for bovine leukemia virus (BLV) using blood was positive, quantitative PCR showed a low number of provirus copies. Autopsy revealed enlargement of most lymph nodes examined, as well as white masses of various sizes in muscles of the left hindlimb and thoracic and abdominal organs. Histopathology revealed severe infiltration with neoplastic lymphocytes in these organs. The cervical mass was immune-positive for B-cell markers. The final diagnosis was thymic B-cell lymphoma with BLV infection.

Citing Articles

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