Systemic Sclerosis - Multidisciplinary Disease: Clinical Features and Treatment

Overview

Journal Reumatologia

Publisher Termedia

Specialty Rheumatology

Date 2019 Sep 25

PMID 31548749

Citations 56

Authors

Piotr Sobolewski

Maria Maslinska

Marta Wieczorek

Zuzanna Lagun

Aleksandra Malewska

Marek Roszkiewicz

Raman Nitskovich

Elzbieta Szymanska

Irena Walecka

Affiliations

Soon will be listed here.

Abstract

Systemic sclerosis is a chronic autoimmune disease of still not fully understood pathogenesis. Fibrosis, vascular wall damage, and disturbances of innate and acquired immune responses with autoantibody production are prominent features. Systemic sclerosis has specific subsets with different autoantibodies, and differences in the affected skin areas. The suspicion of systemic sclerosis and establishing the diagnosis will be facilitated by the criteria created by EULAR/ACR experts. The treatment of this autoimmune disease remains a challenge for clinicians and new therapeutic options are constantly sought. The occurrence of various symptoms and the involvement of many organs and systems make systemic sclerosis a multidisciplinary disease and require a holistic approach. The present article summarizes different clinical features of systemic sclerosis and the profile of autoantibodies and discusses recent rules and future perspectives in disease management.

Citing Articles

Factors Influencing Treatment Satisfaction and Recognition Gaps Between Physicians and Patients with Systemic Sclerosis.

Shima Y, Uchida-Yamada M, Motegi S, Shimada T, Ishii H, Ohya Y Rheumatol Ther. 2025; .

PMID: 39907912 DOI: 10.1007/s40744-025-00745-x.

Artificial intelligence-based cardiovascular/stroke risk stratification in women affected by autoimmune disorders: a narrative survey.

Tiwari E, Shrimankar D, Maindarkar M, Bhagawati M, Kaur J, Singh I Rheumatol Int. 2025; 45(1):14.

PMID: 39745536 DOI: 10.1007/s00296-024-05756-5.

Nutritional disorders and nutrition-related conditions: an underestimated clinical problem in systemic sclerosis.

Wojteczek A, Chmielewski M, Zdrojewski Z Reumatologia. 2024; 62(5):368-380.

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A Rare Case of Juvenile Systemic Sclerosis With Concurrent Disseminated Tuberculosis: Diagnostic and Therapeutic Challenges.

Sahu U, Hasan O, Kumari Y, Mobin N, Shankar M Cureus. 2024; 16(12):e75136.

PMID: 39640412 PMC: 11618662. DOI: 10.7759/cureus.75136.

Assessment of Neutrophil-Lymphocyte Ratio and Systemic Immune-Inflammation Index in Systemic Scleroderma Patients with Focus on Cardiopulmonary Manifestations.

Palici C, Dinescu S, Bita C, Florescu A, Musetescu A, Vreju F Curr Health Sci J. 2024; 50(5):421-427.

PMID: 39574823 PMC: 11578356. DOI: 10.12865/CHSJ.50.03.09.

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