The Neutrophil-to-Lymphocyte Ratio is Related to Disease Activity in Relapsing Remitting Multiple Sclerosis

Overview

Journal Cells

Publisher MDPI

Specialties Biochemistry
Biophysics
Cell Biology
Molecular Biology

Date 2019 Sep 25

PMID 31547008

Citations 24

Authors

Emanuele DAmico

Aurora Zanghi

Alessandra Romano

Mariangela Sciandra

Giuseppe Alberto Maria Palumbo

Francesco Patti

Affiliations

Soon will be listed here.

Abstract

Background: The role of the neutrophil-to-lymphocyte ratio (NLR) of peripheral blood has been investigated in relation to several autoimmune diseases. Limited studies have addressed the significance of the NLR in terms of being a marker of disease activity in multiple sclerosis (MS).

Methods: This is a retrospective study in relapsing-remitting MS patients (RRMS) admitted to the tertiary MS center of Catania, Italy during the period of 1 January to 31 December 2018. The aim of the present study was to investigate the significance of the NLR in reflecting the disease activity in a cohort of early diagnosed RRMS patients.

Results: Among a total sample of 132 patients diagnosed with RRMS, 84 were enrolled in the present study. In the association analysis, a relation between the NLR value and disease activity at onset was found (V-Cramer 0.271, = 0.013). In the logistic regression model, the variable NLR ( = 0.03 ExpB 3.5, CI 95% 1.089-11.4) was related to disease activity at onset.

Conclusion: An elevated NLR is associated with disease activity at onset in RRMS patients. More large-scale studies with a longer follow-up are needed.

Citing Articles

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