Deficiency of PTEN Leads to Aberrant Chromosome Segregation Through Downregulation of MAD2

Overview

Journal Mol Med Rep

Specialty Molecular Biology

Date 2019 Sep 24

PMID 31545428

Citations 2

Authors

Zhuo Sun

Jinqi Lu

Muyu Wu

Mingyan Li

Lu Bai

Zhenduo Shi

Lin Hao

Yongping Wu

Affiliations

Soon will be listed here.

Abstract

Proper spindle formation and accurate chromosome segregation are essential for ensuring mitotic fidelity. Phosphatase and tensin homolog (PTEN) is a multifunctional protein, which is able to maintain the stability of the genome and chromosomes. The present study described an essential role of PTEN in regulating chromosome segregation to prevent gross genomic instability via regulation of mitotic arrest deficient 2 (MAD2). PTEN knockdown induced cell cycle arrest and abnormal chromosome segregation, which manifested as the formation of anaphase bridges, lagging chromosomes and premature chromatid separation. In addition, MAD2 was identified as a potential target of PTEN. Furthermore, the present study revealed that PTEN knockdown resulted in MAD2 degradation via the ubiquitin‑proteasomal pathway, while restoration of MAD2 expression partially ameliorated the mitotic defects induced by PTEN loss. The results from the present study proposed a novel mechanism by which PTEN maintains chromosome stability.

Citing Articles

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