Higher Interleukin-33 Levels in Aggressive Periodontitis Cases

Overview

Journal J Indian Soc Periodontol

Date 2019 Sep 24

PMID 31543615

Citations 3

Authors

Sujatha Pai Ballambettu

A R Pradeep

Meera Purushottam

Somdatta Sen

Affiliations

Soon will be listed here.

Abstract

Context: Interleukin-33 (IL-33) is a novel alarmin that warns immune cells of tissue destruction in injury or infection.

Aims: This study is aimed at analyzing and correlating the concentration of IL-33 in the gingival crevicular fluid (GCF) and plasma of healthy subjects and chronic and aggressive periodontitis patients with intronic variant single nucleotide polymorphisms (SNPs), rs1157505 (C/G) and rs7044343 (C/T) in the IL-33 gene.

Settings And Design: This is a cross-sectional, biochemical, genetic study.

Materials And Methods: Ninety subjects were divided into Group H: subjects with healthy periodontium, Group CP: chronic periodontitis patients, and Group GAgP: generalized aggressive periodontitis patients, based on clinical parameters of periodontal inflammation. IL-33 concentration in GCF, as well as plasma, was quantified using enzyme-linked immunosorbent assay. The SNPs rs1157505 and rs7044343 were analyzed using polymerase chain reaction-restriction fragment length polymorphism.

Results: A significant difference was found in IL-33 concentration in GCF and plasma between the three groups. GG genotype of IL-33 SNP rs1157505 was associated with the highest GCF and plasma IL-33 concentration and was significantly more in GAgP than healthy or CP groups. IL-33 SNP rs7044343 did not show any such association. All GAgP patients had the highest GCF and plasma concentration of IL-33.

Conclusions: IL-33 may be a potential inflammatory marker of periodontitis. GG genotype of SNP rs1157505 may be associated with GAgP.

Citing Articles

Expression of IL-33 in subjects with periodontitis: a systematic review and meta-analysis.

Alarcon-Sanchez M, Romero-Castro N, Reyes-Fernandez S, Sanchez-Tecolapa E, Heboyan A Eur J Med Res. 2024; 29(1):440.

PMID: 39210476 PMC: 11363595. DOI: 10.1186/s40001-024-02039-4.

DAMPs and alarmin gene expression patterns in aging healthy and diseased mucosal tissues.

Gonzalez O, Kirakodu S, Ebersole J Front Oral Health. 2023; 4:1320083.

PMID: 38098978 PMC: 10720672. DOI: 10.3389/froh.2023.1320083.

Cytomorphometric Analysis of Inflammation Dynamics in the Periodontium Following the Use of Fixed Dental Prostheses.

Heboyan A, Syed A, Rokaya D, Cooper P, Manrikyan M, Markaryan M Molecules. 2020; 25(20).

PMID: 33053882 PMC: 7587339. DOI: 10.3390/molecules25204650.

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