Calcium: Magnesium Intake Ratio and Colorectal Carcinogenesis, Results from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial

Overview

Journal Br J Cancer

Specialty Oncology

Date 2019 Sep 24

PMID 31543516

Citations 10

Authors

Jing Zhao

Ayush Giri

Xiangzhu Zhu

Martha J Shrubsole

Yixing Jiang

Xingyi Guo

Reid Ness

Douglas L Seidner

Edward Giovannucci

Todd L Edwards

Qi Dai

Affiliations

Soon will be listed here.

Abstract

Background: We aimed to evaluate the associations between calcium and various stages of colorectal carcinogenesis and whether these associations are modified by the calcium to magnesium (Ca:Mg) ratio.

Methods: We tested our hypotheses in the prostate lung, colorectal and ovarian cancer screening trial.

Results: Calcium intake did not show a dose-response association with incident adenoma of any size/stage (P- = 0.17), but followed an inverse trend when restricted to synchronous/advanced adenoma cases (P- = 0.05). This inverse trend was mainly in participants with Ca:Mg ratios between 1.7 and 2.5 (P- = 0.05). No significant associations were observed for metachronous adenoma. Calcium intake was inversely associated with CRC (P- = 0.03); the association was primarily present for distal CRC (P- = 0.01). The inverse association between calcium and distal CRC was further modified by the Ca:Mg ratio (P- < 0.01); significant dose-response associations were found only in participants with a Ca:Mg ratio between 1.7 and 2.5 (P- = 0.04). No associations for calcium were found in the Ca:Mg ratio above 2.5 or below 1.7.

Conclusion: Higher calcium intake may be related to reduced risks of incident advanced and/or synchronous adenoma and incident distal CRC among subjects with Ca:Mg intake ratios between 1.7 and 2.5.

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References

Hasson M, Fagerstrom R, Kahane D, Walsh J, Myers M, Caughman C . Design and evolution of the data management systems in the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials. 2001; 21(6 Suppl):329S-348S. DOI: 10.1016/s0197-2456(00)00100-8. View

Liu S, Liu Q . Personalized magnesium intervention to improve vitamin D metabolism: applying a systems approach for precision nutrition in large randomized trials of diverse populations. Am J Clin Nutr. 2018; 108(6):1159-1161. PMC: 6290361. DOI: 10.1093/ajcn/nqy294. View

Rosanoff A, Dai Q, Shapses S . Essential Nutrient Interactions: Does Low or Suboptimal Magnesium Status Interact with Vitamin D and/or Calcium Status?. Adv Nutr. 2016; 7(1):25-43. PMC: 4717874. DOI: 10.3945/an.115.008631. View

Zhang X, Giovannucci E . Calcium, vitamin D and colorectal cancer chemoprevention. Best Pract Res Clin Gastroenterol. 2011; 25(4-5):485-94. DOI: 10.1016/j.bpg.2011.10.001. View

Dai Q, Cantwell M, Murray L, Zheng W, Anderson L, Coleman H . Dietary magnesium, calcium:magnesium ratio and risk of reflux oesophagitis, Barrett's oesophagus and oesophageal adenocarcinoma: a population-based case-control study. Br J Nutr. 2015; 115(2):342-50. DOI: 10.1017/S0007114515004444. View

Li K, Kaaks R, Linseisen J, Rohrmann S . Dietary calcium and magnesium intake in relation to cancer incidence and mortality in a German prospective cohort (EPIC-Heidelberg). Cancer Causes Control. 2011; 22(10):1375-82. DOI: 10.1007/s10552-011-9810-z. View

Schoen R, Pinsky P, Weissfeld J, Yokochi L, Church T, Laiyemo A . Colorectal-cancer incidence and mortality with screening flexible sigmoidoscopy. N Engl J Med. 2012; 366(25):2345-57. PMC: 3641846. DOI: 10.1056/NEJMoa1114635. View

Kitahara C, Berndt S, Berrington de Gonzalez A, Coleman H, Schoen R, Hayes R . Prospective investigation of body mass index, colorectal adenoma, and colorectal cancer in the prostate, lung, colorectal, and ovarian cancer screening trial. J Clin Oncol. 2013; 31(19):2450-9. PMC: 3691360. DOI: 10.1200/JCO.2012.48.4691. View

Prorok P, Andriole G, Bresalier R, Buys S, Chia D, Crawford E . Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control Clin Trials. 2001; 21(6 Suppl):273S-309S. DOI: 10.1016/s0197-2456(00)00098-2. View

10.

Wu K, Willett W, Fuchs C, Colditz G, Giovannucci E . Calcium intake and risk of colon cancer in women and men. J Natl Cancer Inst. 2002; 94(6):437-46. DOI: 10.1093/jnci/94.6.437. View

11.

Kronborg O, Fenger C . Clinical evidence for the adenoma-carcinoma sequence. Eur J Cancer Prev. 2000; 8 Suppl 1:S73-86. View

12.

Baxter N, Goldwasser M, Paszat L, Saskin R, Urbach D, Rabeneck L . Association of colonoscopy and death from colorectal cancer. Ann Intern Med. 2008; 150(1):1-8. DOI: 10.7326/0003-4819-150-1-200901060-00306. View

13.

Wactawski-Wende J, Kotchen J, Anderson G, Assaf A, Brunner R, OSullivan M . Calcium plus vitamin D supplementation and the risk of colorectal cancer. N Engl J Med. 2006; 354(7):684-96. DOI: 10.1056/NEJMoa055222. View

14.

Espey D, Wu X, Swan J, Wiggins C, Jim M, Ward E . Annual report to the nation on the status of cancer, 1975-2004, featuring cancer in American Indians and Alaska Natives. Cancer. 2007; 110(10):2119-52. DOI: 10.1002/cncr.23044. View

15.

Zhang X, Keum N, Wu K, Smith-Warner S, Ogino S, Chan A . Calcium intake and colorectal cancer risk: Results from the nurses' health study and health professionals follow-up study. Int J Cancer. 2016; 139(10):2232-42. PMC: 5017917. DOI: 10.1002/ijc.30293. View

16.

Crockett S, Barry E, Mott L, Ahnen D, Robertson D, Anderson J . Calcium and vitamin D supplementation and increased risk of serrated polyps: results from a randomised clinical trial. Gut. 2018; 68(3):475-486. PMC: 6286251. DOI: 10.1136/gutjnl-2017-315242. View

17.

Baron J, Barry E, Mott L, Rees J, Sandler R, Snover D . A Trial of Calcium and Vitamin D for the Prevention of Colorectal Adenomas. N Engl J Med. 2015; 373(16):1519-30. PMC: 4643064. DOI: 10.1056/NEJMoa1500409. View

18.

Rim S, Seeff L, Ahmed F, King J, Coughlin S . Colorectal cancer incidence in the United States, 1999-2004 : an updated analysis of data from the National Program of Cancer Registries and the Surveillance, Epidemiology, and End Results Program. Cancer. 2009; 115(9):1967-76. DOI: 10.1002/cncr.24216. View

19.

Boutron M, Faivre J, Marteau P, Couillault C, Senesse P, Quipourt V . Calcium, phosphorus, vitamin D, dairy products and colorectal carcinogenesis: a French case--control study. Br J Cancer. 1996; 74(1):145-51. PMC: 2074613. DOI: 10.1038/bjc.1996.330. View

20.

Carroll C, Cooper K, Papaioannou D, Hind D, Pilgrim H, Tappenden P . Supplemental calcium in the chemoprevention of colorectal cancer: a systematic review and meta-analysis. Clin Ther. 2010; 32(5):789-803. DOI: 10.1016/j.clinthera.2010.04.024. View