Mouse Models As Resources for Studying Infectious Diseases

Overview

Journal Clin Ther

Specialty Pharmacology

Date 2019 Sep 22

PMID 31540729

Citations 35

Authors

Sanjay Sarkar

Mark T Heise

Affiliations

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Abstract

Mouse models are important tools both for studying the pathogenesis of infectious diseases and for the preclinical evaluation of vaccines and therapies against a wide variety of human pathogens. The use of genetically defined inbred mouse strains, humanized mice, and gene knockout mice has allowed the research community to explore how pathogens cause disease, define the role of specific host genes in either controlling or promoting disease, and identify potential targets for the prevention or treatment of a wide range of infectious agents. This review discusses several of the most commonly used mouse model systems, as well as new resources such as the Collaborative Cross as models for studying infectious diseases.

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References

Buddle B, Vordermeier H, Hewinson R . Experimental Infection Models of Tuberculosis in Domestic Livestock. Microbiol Spectr. 2016; 4(4). DOI: 10.1128/microbiolspec.TBTB2-0017-2016. View

Zhang J, Malo D, Mott R, Panthier J, Montagutelli X, Jaubert J . Identification of new loci involved in the host susceptibility to Salmonella Typhimurium in collaborative cross mice. BMC Genomics. 2018; 19(1):303. PMC: 5923191. DOI: 10.1186/s12864-018-4667-0. View

Gralinski L, Ferris M, Aylor D, Whitmore A, Green R, Frieman M . Genome Wide Identification of SARS-CoV Susceptibility Loci Using the Collaborative Cross. PLoS Genet. 2015; 11(10):e1005504. PMC: 4599853. DOI: 10.1371/journal.pgen.1005504. View

Smith C, Proulx M, Olive A, Laddy D, Mishra B, Moss C . Tuberculosis Susceptibility and Vaccine Protection Are Independently Controlled by Host Genotype. mBio. 2016; 7(5). PMC: 5030360. DOI: 10.1128/mBio.01516-16. View

Bottomly D, Ferris M, Aicher L, Rosenzweig E, Whitmore A, Aylor D . Expression quantitative trait Loci for extreme host response to influenza a in pre-collaborative cross mice. G3 (Bethesda). 2012; 2(2):213-21. PMC: 3284329. DOI: 10.1534/g3.111.001800. View

Doetschman T, Gregg R, Maeda N, Hooper M, Melton D, Thompson S . Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature. 1987; 330(6148):576-8. DOI: 10.1038/330576a0. View

Masopust D, Sivula C, Jameson S . Of Mice, Dirty Mice, and Men: Using Mice To Understand Human Immunology. J Immunol. 2017; 199(2):383-388. PMC: 5512602. DOI: 10.4049/jimmunol.1700453. View

Caine E, Scheaffer S, Arora N, Zaitsev K, Artyomov M, Coyne C . Interferon lambda protects the female reproductive tract against Zika virus infection. Nat Commun. 2019; 10(1):280. PMC: 6336786. DOI: 10.1038/s41467-018-07993-2. View

Valbuena G, Halliday H, Borisevich V, Goez Y, Rockx B . A human lung xenograft mouse model of Nipah virus infection. PLoS Pathog. 2014; 10(4):e1004063. PMC: 3974875. DOI: 10.1371/journal.ppat.1004063. View

10.

Sims A, Baric R, Yount B, Burkett S, Collins P, Pickles R . Severe acute respiratory syndrome coronavirus infection of human ciliated airway epithelia: role of ciliated cells in viral spread in the conducting airways of the lungs. J Virol. 2005; 79(24):15511-24. PMC: 1316022. DOI: 10.1128/JVI.79.24.15511-15524.2005. View

11.

Baseler L, de Wit E, Feldmann H . A Comparative Review of Animal Models of Middle East Respiratory Syndrome Coronavirus Infection. Vet Pathol. 2016; 53(3):521-31. DOI: 10.1177/0300985815620845. View

12.

Rall G, Manchester M, DANIELS L, Callahan E, Belman A, Oldstone M . A transgenic mouse model for measles virus infection of the brain. Proc Natl Acad Sci U S A. 1997; 94(9):4659-63. PMC: 20780. DOI: 10.1073/pnas.94.9.4659. View

13.

Torraca V, Mostowy S . Zebrafish Infection: From Pathogenesis to Cell Biology. Trends Cell Biol. 2017; 28(2):143-156. PMC: 5777827. DOI: 10.1016/j.tcb.2017.10.002. View

14.

Peck K, Cockrell A, Yount B, Scobey T, Baric R, Heise M . Glycosylation of mouse DPP4 plays a role in inhibiting Middle East respiratory syndrome coronavirus infection. J Virol. 2015; 89(8):4696-9. PMC: 4442375. DOI: 10.1128/JVI.03445-14. View

15.

Enkirch T, von Messling V . Ferret models of viral pathogenesis. Virology. 2015; 479-480:259-70. PMC: 7111696. DOI: 10.1016/j.virol.2015.03.017. View

16.

Meier K, Gardner C, Khoretonenko M, Klimstra W, Ryman K . A mouse model for studying viscerotropic disease caused by yellow fever virus infection. PLoS Pathog. 2009; 5(10):e1000614. PMC: 2749449. DOI: 10.1371/journal.ppat.1000614. View

17.

Balla K, Troemel E . Caenorhabditis elegans as a model for intracellular pathogen infection. Cell Microbiol. 2013; 15(8):1313-22. PMC: 3894601. DOI: 10.1111/cmi.12152. View

18.

Grant A, Ponia S, Tripathi S, Balasubramaniam V, Miorin L, Sourisseau M . Zika Virus Targets Human STAT2 to Inhibit Type I Interferon Signaling. Cell Host Microbe. 2016; 19(6):882-90. PMC: 4900918. DOI: 10.1016/j.chom.2016.05.009. View

19.

Palha N, Guivel-Benhassine F, Briolat V, Lutfalla G, Sourisseau M, Ellett F . Real-time whole-body visualization of Chikungunya Virus infection and host interferon response in zebrafish. PLoS Pathog. 2013; 9(9):e1003619. PMC: 3764224. DOI: 10.1371/journal.ppat.1003619. View

20.

Lambkin-Williams R, Noulin N, Mann A, Catchpole A, Gilbert A . The human viral challenge model: accelerating the evaluation of respiratory antivirals, vaccines and novel diagnostics. Respir Res. 2018; 19(1):123. PMC: 6013893. DOI: 10.1186/s12931-018-0784-1. View